Application of UV dissolution imaging to pharmaceutical systems q

被引：12

作者：

Brown, Benedict ^{[1
,2
]}

Ward, Adam ^{[1
,2
]}

Fazili, Zayeem ^{[1
,2
,3
]}

ostergaard, Jesper ^{[4
]}

Asare-Addo, Kofi ^{[1
]}

机构：

[1] Univ Huddersfield, Dept Pharm, Huddersfield HD1 3DH, W Yorkshire, England

[2] Univ Huddersfield, EPSRC Future Metrol Hub, Huddersfield HD1 3DH, W Yorkshire, England

[3] Univ Huddersfield, Dept Comp & Engn, Huddersfield HD1 3DH, W Yorkshire, England

[4] Univ Copenhagen, Dept Pharm, Univ Pk 2, DK-2100 Copenhagen O, Denmark

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2021年 / 177卷

基金：

英国工程与自然科学研究理事会;

关键词：

Diffusion; Dissolution testing; Intrinsic dissolution rate; In-vitro release; Parenterals; UV imaging; IN-VITRO RELEASE; NEAR-INFRARED SPECTROSCOPY; AMORPHOUS SOLID DISPERSIONS; HYDROGEL MATRIX MIMICKING; GLYCOLIDE ACID IMPLANTS; GEL-LAYER FORMATION; DRUG-RELEASE; INTRINSIC DISSOLUTION; SUSTAINED-RELEASE; VIVO PERFORMANCE;

D O I：

10.1016/j.addr.2021.113949

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

UV-vis spectrometry is widely used in the pharmaceutical sciences for compound quantification, alone or in conjunction with separation techniques, due to most drug entities possessing a chromophore absorbing light in the range 190-800 nm. UV dissolution imaging, the scope of this review, generates spatially and temporally resolved absorbance maps by exploiting the UV absorbance of the analyte. This review aims to give an introduction to UV dissolution imaging and its use in the determination of intrinsic dissolution rates and drug release from whole dosage forms. Applications of UV imaging to non-oral formulations have started to emerge and are reviewed together with the possibility of utilizing UV imaging for physical chemical characterisation of drug substances. The benefits of imaging drug diffusion and transport processes are also discussed. (c) 2021 Elsevier B.V. All rights reserved.

引用

页数：26

共 245 条

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