Fatality Involving the Ingestion of Phenazepam and Poppy Seed Tea

被引:44
作者
Bailey, Kristen [1 ]
Richards-Waugh, Lauren [1 ]
Clay, David [1 ]
Gebhardt, Myron [1 ]
Mahmoud, Hamada [1 ]
Kraner, James C. [1 ]
机构
[1] Off Chief Med Examiner, Charleston, WV USA
关键词
URINE; METABOLITES; CONSUMPTION; EXCRETION; OVERDOSE; MORPHINE; HEROIN; ABUSE; BLOOD;
D O I
10.1093/jat/34.8.527
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Phenazepam is a benzodiazepine derivative that has been in clinical use in Russia since 1978 and is not available by prescription in the United States; however, it is attainable through various internet websites, sold either as tablets or as a referencegrade crystalline powder. Presented here is the case of a 42-yearold Caucasian male who died as the result of combined phenazepam, morphine, codeine, and thebaine intoxication. A vial of white powder labeled "Phenazepam, Purity 99%, CAS No. 51753-57-2, Research Sample", a short straw, and several poppy seed pods were found on the scene. Investigation revealed that the decedent had a history of ordering medications over the internet and that he had consumed poppy seed tea prior to his death. Phenazepam, morphine, codeine, and thebaine were present in the blood at 386, 116, 85, and 72 ng/mL, respectively. © 2010 Publishing Technology.
引用
收藏
页码:527 / 532
页数:6
相关论文
共 25 条
[1]  
[Anonymous], DISPOSITION TOXIC DR
[2]  
[Anonymous], 2004, ANN M SOC FOR TOX WA
[3]   Poppy seed tea and opiate abuse in New Zealand [J].
Braye, Klare ;
Harwood, Thomas ;
Inder, Rachel ;
Beasley, Richard ;
Robinson, Geoffrey .
DRUG AND ALCOHOL REVIEW, 2007, 26 (02) :215-219
[4]   The analysis of thebaine in urine for the detection of poppy seed consumption [J].
Cassella, G ;
Wu, AHB ;
Shaw, BR ;
Hill, DW .
JOURNAL OF ANALYTICAL TOXICOLOGY, 1997, 21 (05) :376-383
[5]   The effects of methadone and its role in fatalities [J].
Corkery, JM ;
Schifano, F ;
Ghodse, AH ;
Oyefeso, A .
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL, 2004, 19 (08) :565-576
[6]   Two UK suicides using nicotine extracted from tobacco employing instructions available on the Internet [J].
Corkery, John M. ;
Button, Jennifer ;
Vento, Alessandro E. ;
Schifano, Fabrizio .
FORENSIC SCIENCE INTERNATIONAL, 2010, 199 (1-3) :E9-E13
[7]   The internet as a source of drugs of abuse [J].
Forman R.F. ;
Marlowe D.B. ;
McLellan A.T. .
Current Psychiatry Reports, 2006, 8 (5) :377-382
[8]   Patterns of Abuse Among Unintentional Pharmaceutical Overdose Fatalities [J].
Hall, Aron J. ;
Logan, Joseph E. ;
Toblin, Robin L. ;
Kaplan, James A. ;
Kraner, James C. ;
Bixler, Danae ;
Crosby, Alex E. ;
Paulozzi, Leonard J. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2008, 300 (22) :2613-2620
[9]   Determination of γ-hydroxybutyrate (GHB) and its precursors in blood and urine samples:: A salting-out approach [J].
Kankaanpaa, Aino ;
Liukkonen, Raija ;
Ariniemi, Kari .
FORENSIC SCIENCE INTERNATIONAL, 2007, 170 (2-3) :133-138
[10]   Determination of Heroin and Its Main Metabolites in Small Sample Volumes of Whole Blood and Brain Tissue by Reversed-Phase Liquid Chromatography-Tandem Mass Spectrometry [J].
Karinen, Ritva ;
Andersen, Jannike Morch ;
Ripel, Ase ;
Hasvold, Inger ;
Hopen, Anita Braute ;
Morland, Jorg ;
Christophersen, Asbjorg S. .
JOURNAL OF ANALYTICAL TOXICOLOGY, 2009, 33 (07) :345-350