In Vitro Antibacterial Activity of Cefiderocol against Multidrug-Resistant Acinetobacter baumannii

被引：37

作者：

Abdul-Mutakabbir, Jacinda C. ^{[1
,6
]}

Nguyen, Logan ^{[1
]}

Maassen, Philip T. ^{[1
]}

Stamper, Kyle C. ^{[1
]}

Kebriaei, Razieh ^{[1
]}

Kaye, Keith S. ^{[2
]}

Castanheira, Mariana ^{[3
]}

Rybak, Michael J. ^{[1
,4
,5
]}

机构：

[1] Wayne State Univ, Antiinfect Res Lab, Dept Pharm Practice, Eugene Applebaum Coll Pharm & Hlth Sci, Detroit, MI 48202 USA

[2] Univ Michigan, Div Infect Dis, Med Sch, Ann Arbor, MI 48109 USA

[3] JMI Labs, North Liberty, IA USA

[4] Wayne State Univ, Sch Med, Dept Med, Div Infect Dis, Detroit, MI 48201 USA

[5] Detroit Receiving Hosp & Univ Hlth Ctr, Detroit Med Ctr, Dept Pharm Serv, Detroit, MI 48201 USA

[6] Loma Linda Univ, Sch Pharm, Loma Linda, CA 92350 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2021年 / 65卷 / 09期

关键词：

A; baumannii; Gram-negative; cefiderocol; multidrug-resistant infection; CEFTAZIDIME-AVIBACTAM; EXTENDED-SPECTRUM; SURVEILLANCE; EPIDEMIOLOGY; COLISTIN;

D O I：

10.1128/AAC.02646-20

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cefiderocol (CFDC), a novel siderophore cephalosporin, demonstrates strong activity against multidrug-resistant (MDR) Acinetobacter baumannii. Limited studies have evaluated CFDC alone and in combination with other Gram-negative antibiotics against MDR A. baumannii isolates. Susceptibility testing revealed lower CFDC MIC values (87% of MICs <= 4mg/liter) than the comparator Gram-negative agents. Six isolates, with elevated CFDC MICs (16 to 32 mg/liter) were selected for further experiments. Time-kill analyses presented with synergistic activity and beta-lactamase inhibitors increased CFDC susceptibility in each of the isolates.

引用

页数：6

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