Hepatitis C virus infection increases the risk of developing peripheral arterial disease: A 9-year population-based cohort study

被引：60

作者：

Hsu, Yueh-Han ^{[1
,2
,3
,4
]}

Muo, Chih-Hsin ^{[5
,6
]}

Liu, Chun-Yi ^{[1
,2
]}

Tsai, Wen-Chen ^{[1
,2
]}

Hsu, Chih-Cheng ^{[7
,8
]}

Sung, Fung-Chang ^{[9
,10
]}

Kao, Chia-Hung ^{[9
,10
,11
,12
]}

机构：

[1] China Med Univ, Dept Publ Hlth, Taichung 404, Taiwan

[2] China Med Univ, Dept Hlth Serv Adm, Taichung 404, Taiwan

[3] Ditmanson Med Fdn Chia Yi Christian Hosp, Div Nephrol, Dept Internal Med, Chiayi 600, Taiwan

[4] Min Hwei Junior Coll Hlth Care Management, Dept Nursing, Tainan 736, Taiwan

[5] China Med Univ Hosp, Management Off Hlth Data, Taichung 404, Taiwan

[6] China Med Univ, Sch Med, Taichung 404, Taiwan

[7] Natl Hlth Res Inst, Inst Populat Hlth Sci, Zhunan 35053, Miaoli County, Taiwan

[8] China Med Univ & Hosp, Dept Hlth Serv Adm, Taichung 404, Taiwan

[9] China Med Univ, Coll Med, Grad Inst Clin Med Sci, Taichung 404, Taiwan

[10] China Med Univ, Coll Med, Sch Med, Taichung 404, Taiwan

[11] China Med Univ Hosp, Dept Nucl Med, Taichung 404, Taiwan

[12] China Med Univ Hosp, PET Ctr, Taichung 404, Taiwan

来源：

JOURNAL OF HEPATOLOGY | 2015年 / 62卷 / 03期

关键词：

Cardiovascular disease; Chronic kidney disease; Comorbidity; Hepatitis; Peripheral arterial disease; Stroke; NUTRITION EXAMINATION SURVEY; NATIONAL-HEALTH; INSULIN-RESISTANCE; PREVALENCE; TAIWAN; ATHEROSCLEROSIS; ASSOCIATIONS; OUTCOMES; IMPACT;

D O I：

10.1016/j.jhep.2014.09.022

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background & Aims: The relationship between hepatitis C virus (HCV) infection and peripheral arterial disease (PAD) development remains unclear. Methods: Health insurance claims data were used to construct a cohort of HCV-infected patients diagnosed during the period 1998-2011. Patients younger than 20 years and those with history of hepatitis B or PAD were excluded. We selected 7641 HCV-infected patients and 30564 matched controls. The adjusted risk of developing PAD was analyzed using a multivariate Cox hazard model. Results: The results show that the excess risk of PAD development in HCV-infected patients is 1.43-fold higher (95% CI = 1.23-1.67) compared with non-HCV patients. The adjusted risk of PAD development increases with age; compared with the 20-34 year-old patients, the risk is 3.96-fold higher in HCVinfected patients aged 35-49 years, and 11.7-fold higher in those aged 65 years and above. CKD/ESRD has the highest risk for PAD (HR = 1.80, 95% CI = 1.29-2.53). HCV-infected patients with four comorbidities exhibit a substantially higher risk of developing PAD (HR = 9.25, 95% CI = 6.35-13.5). Excess risk of developing PAD is observed from the first year of follow-up till the third year. Conclusion: HCV-infected patients have an independently higher risk of developing PAD. HCV-infected patients with comorbidity have increased risk of developing PAD. (C) 2014 European Association for the Study of the Liver. Published by Elsevier B. V. All rights reserved.

引用

页码：519 / 525

页数：7

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