Ultrasound-assisted efficient synthesis of polyfunctional 1,2,4-triazoles as novel antibacterial and antioxidant agents

被引:4
作者
Dastmard, Sahar [1 ]
Mamaghani, Manouchehr [1 ]
Rassa, Mehdi [2 ]
机构
[1] Univ Guilan, Dept Chem, Fac Sci, POB 41335-1914, Rasht, Iran
[2] Univ Guilan, Dept Biol, Fac Sci, Rasht, Iran
关键词
antibacterial activity; antioxidant activity; ultrasound irradiation; imidazole; 1; 2; 4-triazole; BIOLOGICAL EVALUATION; MULTICOMPONENT SYNTHESIS; GREEN SYNTHESIS; IMIDAZOLES; DERIVATIVES; ACID;
D O I
10.1002/jccs.201900430
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Novel 4,5-diphenyl-1H-imidazol-1-yl-1H-1,2,4-triazole derivatives were synthesized using a facile and highly efficient, one-pot, four-component procedure in the presence of KHSO4 as an acidic catalyst under ultrasonic irradiations in short reaction times (10-25 min) and good to excellent yields (70-96%). The synthesized compounds were screened for their antibacterial activities against Gram-negative (Escherichia coli, Pseudomonas aeruginosa) and Gram-positive (Bacillus subtilis, Micrococcus luteus) bacteria, and their antioxidant activity was also evaluated. Some of the products showed potential antibacterial and high antioxidant activities.
引用
收藏
页码:1437 / 1445
页数:9
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