Ultrasound-assisted efficient synthesis of polyfunctional 1,2,4-triazoles as novel antibacterial and antioxidant agents

被引：4

作者：

Dastmard, Sahar ^{[1
]}

Mamaghani, Manouchehr ^{[1
]}

Rassa, Mehdi ^{[2
]}

机构：

[1] Univ Guilan, Dept Chem, Fac Sci, POB 41335-1914, Rasht, Iran

[2] Univ Guilan, Dept Biol, Fac Sci, Rasht, Iran

来源：

JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2020年 / 67卷 / 08期

关键词：

antibacterial activity; antioxidant activity; ultrasound irradiation; imidazole; 1; 2; 4-triazole; BIOLOGICAL EVALUATION; MULTICOMPONENT SYNTHESIS; GREEN SYNTHESIS; IMIDAZOLES; DERIVATIVES; ACID;

D O I：

10.1002/jccs.201900430

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel 4,5-diphenyl-1H-imidazol-1-yl-1H-1,2,4-triazole derivatives were synthesized using a facile and highly efficient, one-pot, four-component procedure in the presence of KHSO4 as an acidic catalyst under ultrasonic irradiations in short reaction times (10-25 min) and good to excellent yields (70-96%). The synthesized compounds were screened for their antibacterial activities against Gram-negative (Escherichia coli, Pseudomonas aeruginosa) and Gram-positive (Bacillus subtilis, Micrococcus luteus) bacteria, and their antioxidant activity was also evaluated. Some of the products showed potential antibacterial and high antioxidant activities.

引用

页码：1437 / 1445

页数：9

共 58 条

[1] The first protection-free synthesis of magnetic bifunctional L-proline as a highly active and versatile artificial enzyme: Synthesis of imidazole derivatives [J].

Aghahosseini, Hamideh ;

Ramazani, Ali ;

Slepokura, Katarzyna ;

Lis, Tadeusz .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2018, 511 :222-232

[2] Ultrasound-assisted facile one-pot sequential synthesis of novel sulfonamideisoxazoles using cerium (IV) ammonium nitrate (CAN) as an efficient oxidant in aqueous medium [J].

Alaoui, Soukaina ;

Driowya, Mohsine ;

Demange, Luc ;

Benhida, Rachid ;

Bougrin, Khalid .

ULTRASONICS SONOCHEMISTRY, 2018, 40 :289-297

[3] Solvent-free Multicomponent Synthesis of Biologically-active Fused-imidazo Heterocycles Catalyzed by Reusable Yb(OTf)3 Under Microwave Irradiation [J].

Ansari, Arshad J. ;

Sharma, Shivani ;

Pathare, Ramdas S. ;

Gopal, Kandasamy ;

Sawant, Devesh M. ;

Pardasani, R. T. .

CHEMISTRYSELECT, 2016, 1 (05) :1016-1021

[4] Free radicals, oxidative stress, and antioxidants in human health and disease [J].

Aruoma, OI .

JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 1998, 75 (02) :199-212

[5] Recent developments on ultrasound-assisted one-pot multicomponent synthesis of biologically relevant heterocycles [J].

Banerjee, Bubun .

ULTRASONICS SONOCHEMISTRY, 2017, 35 :15-35

[6]

Baron EJ, 1990, BAILEY SCOTTS DIAGNO, P1

[7] Synthesis and Biological Evaluation of New Thiosemicarbazone Derivative Schiff Bases as Monoamine Oxidase Inhibitory Agents [J].

Cavusoglu, Betuel Kaya ;

Saglik, Beguem Nurpelin ;

Osmaniye, Derya ;

Levent, Serkan ;

Cevik, Ulviye Acar ;

Karaduman, Abdullah Burak ;

Ozkay, Yusuf ;

Kaplancikli, Zafer Asim .

MOLECULES, 2018, 23 (01)

[8] Multitargeted Imidazoles: Potential Therapeutic Leads for Alzheimer's and Other Neurodegenerative Diseases [J].

Cornec, Anne-Sophie ;

Monti, Ludovica ;

Kovalevich, Jane ;

Makani, Vishruti ;

James, Michael J. ;

Vijayendran, Krishna G. ;

Oukoloff, Killian ;

Yao, Yuemang ;

Lee, Virginia M. -Y. ;

Trojanowski, John Q. ;

Smith, Amos B., III ;

Brunden, Kurt R. ;

Ballatore, Carlo .

JOURNAL OF MEDICINAL CHEMISTRY, 2017, 60 (12) :5120-5145

[9]

Dua R., 2011, Adv. Biol. Res, V5, P120, DOI DOI 10.1023/B:SOLA.0000013030.09729.38

[10] Antiviral activity of pyrrole-imidazole polyamides against SV40 and BK polyomaviruses [J].

Edwards, Terri G. ;

Fisher, Chris .

ANTIVIRAL RESEARCH, 2018, 152 :68-75

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