Ultrasound-assisted efficient synthesis of polyfunctional 1,2,4-triazoles as novel antibacterial and antioxidant agents

被引：6

作者：

Dastmard, Sahar ^{[1
]}

Mamaghani, Manouchehr ^{[1
]}

Rassa, Mehdi ^{[2
]}

机构：

[1] Univ Guilan, Dept Chem, Fac Sci, POB 41335-1914, Rasht, Iran

[2] Univ Guilan, Dept Biol, Fac Sci, Rasht, Iran

来源：

JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2020年 / 67卷 / 08期

关键词：

antibacterial activity; antioxidant activity; ultrasound irradiation; imidazole; 1; 2; 4-triazole; BIOLOGICAL EVALUATION; MULTICOMPONENT SYNTHESIS; GREEN SYNTHESIS; IMIDAZOLES; DERIVATIVES; ACID;

D O I：

10.1002/jccs.201900430

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel 4,5-diphenyl-1H-imidazol-1-yl-1H-1,2,4-triazole derivatives were synthesized using a facile and highly efficient, one-pot, four-component procedure in the presence of KHSO4 as an acidic catalyst under ultrasonic irradiations in short reaction times (10-25 min) and good to excellent yields (70-96%). The synthesized compounds were screened for their antibacterial activities against Gram-negative (Escherichia coli, Pseudomonas aeruginosa) and Gram-positive (Bacillus subtilis, Micrococcus luteus) bacteria, and their antioxidant activity was also evaluated. Some of the products showed potential antibacterial and high antioxidant activities.

引用

页码：1437 / 1445

页数：9

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