Photo-induced eradication of human colorectal adenocarcinoma HT-29 cells by carbon monoxide (CO) delivery from a Mn-based green luminescent photoCORM

被引：23

作者：

Jimenez, Jorge ^{[1
]}

Pinto, Miguel N. ^{[1
]}

Martinez-Gonzalez, Jorge ^{[1
]}

Mascharak, Pradip K. ^{[1
]}

机构：

[1] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA

来源：

INORGANICA CHIMICA ACTA | 2019年 / 485卷

关键词：

VISIBLE-LIGHT; TRICARBONYL COMPLEX; BIOLOGICAL TARGETS; CELLULAR TARGETS; MALIGNANT-CELLS; CANCER CELLS; RELEASE; MOLECULES; PHOTOTOXICITY; EXPOSURE;

D O I：

10.1016/j.ica.2018.09.088

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Exogenous CO delivery to cellular targets for salutary purposes can be readily achieved with photoactive metal carbonyl complexes (photoCORMs). Mn(I)-based photoCORMs are often favored for their ability to release CO upon triggering with visible light (suitable for phototherapy of cancer). To date, the reported Mn(I)based photoCORMs are all non-luminescent and hence the entry of these CO donors cannot be tracked within the targeted sites. A new luminescent Mn(I) photoCORM namely [Mn(CO)(3)(phen)(Pipdansyl)](CF3SO3) (3) has been reported. Synthetic strategy to isolate photoCORM(3) and its previous analogue [Mn (CO)(3)(phen)(Imdansyl)](CF3SO3) (2) has been highlighted to establish protocols for the future isolation of luminescent Mn(I)-based photoCORMs that could be employed as trackable photoCORMs for CO delivery. The entrance of 3 into human colorectal adenocarcinoma HT-29 cells has been visualized by confocal microscopic studies. Eradication of the cancer cells by CO delivery from 3 under visible light illumination has also been demonstrated.

引用

页码：112 / 117

页数：6

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