Angiogenesis and hematologic malignancy

被引：0
作者：
Zini, Jean-Marc [1 ]
Tobelem, Gerard [1 ]
机构：
[1] Hop Lariboisiere, Serv Angiohematol, F-75010 Paris, France
来源：
BULLETIN DU CANCER | 2007年 / 94卷
关键词：
angiogenesis; hematologic malignancy;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Angiogenesis plays an important role in the progression of tumors. This relationship has been described in several hematologic malignancies, Vascular endothelial growth factor and basic fibroblast growth factor are Predictors of poor prognosis in leukemia and non Hodgkin's lymphoma. Bone marrow microvessels were found increased in multiple myeloma, but also in lymphoma and in acute lymphoblastic leukemia. Microvessel density is correlated with decreased survival in myeloma patients and relapse or resistance to chemotherapy in lymphoma. New drugs with antiangiogenic activity such as bevacizumab (binding and inactivation of VEGF) or VEGF-tyrosine kinase inhibitors have shown promising results in phase I trials. It will therefore be a future challenge to integrate anti-angiogenesis agents in currently existing treatment protocols to improve the outcome of therapy.
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收藏
页码：S241 / S246
页数：6
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