Organocatalytic asymmetiric α-selenenylation of aldehydes

被引：92

作者：

Tiecco, Marcello

Carlone, Armando

Sternativo, Silvia

Marini, Francesca ^{[1
]}

Bartoli, Giuseppe

Melchiorre, Paolo

机构：

[1] Univ Perugia, Sez Chim Organ, Dipartimento Chim & Tecnol Farmaco, I-06123 Perugia, Italy

[2] Univ Bologna, Dipartimento Chim Organ A Mangini, I-40136 Bologna, Italy

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 36期

关键词：

aldehydes; asymmetric synthesis; organocatalysis; selenium; synthetic methods;

D O I：

10.1002/anie.200702318

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Getting round the (periodic) table: The enamine activation concept has been extended to the asymmetric addition of selenium-based compounds to aldehydes in an organocatalytic transformation that provides high reaction efficiency and stereocontrol (ee values ranging from 95 to 99%) with readily available chiral secondary amines. The chiral α-seleno aldehydes thus formed can be used as versatile intermediates. © 2007 Wiley-VCH Verlag GmbH &. Co. KGaA.

引用

页码：6882 / 6885

页数：4

共 65 条

[1] Organocatalytic asymmetric Friedel-Crafts alkylation of indoles with simple α,β-unsaturated ketones [J].