Progression of Pneumoconiosis in Coal Miners after Cessation of Dust Exposure: A Longitudinal Study Based on Periodic Chest X-ray Examinations in Hokkaido, Japan

被引：23

作者：

Kimura, Kiyonobu ^{[1
]}

Ohtsuka, Yoshinori ^{[1
]}

Kaji, Hiroshi ^{[1
]}

Nakano, Ikuo ^{[1
]}

Sakai, Ichiro ^{[1
]}

Itabashi, Koichi ^{[1
]}

Igarashi, Takeshi ^{[1
]}

Okamoto, Kenzo ^{[1
]}

机构：

[1] Japan Labor Hlth & Welf Org, Hokkaido Chuo Rosai Hosp, Workmens Accid Compensat Hosp, Clin Res Ctr Pneumoconiosis, Iwamizawa, Japan

来源：

INTERNAL MEDICINE | 2010年 / 49卷 / 18期

关键词：

pneumoconiosis; coal miner; ex-miner; natural history; periodic medical examination; FACTOR-ALPHA GENE; MASSIVE FIBROSIS; FOLLOW-UP; RADIOLOGICAL PROGRESSION; WORKERS PNEUMOCONIOSIS; SILICOSIS; POLYMORPHISMS; PROMOTER; RISK; TNF;

D O I：

10.2169/internalmedicine.49.2990

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background The progression rate of pneumoconiosis in retired coal miners over ten years has not been studied in Japan. Methods A retrospective longitudinal study was undertaken using chest X-rays of 1091 pneumoconiosis subjects in Hokkaido, Japan between 1985 and 2005. Results The final numbers of subjects were 207 (19% of the entry) after 1 decade and 85 (8%) after 2 decades. Sixty-two percent of 207 subjects after 1 decade and 29% of 85 showed progression in 2 decades. Thirty-one percent of ILO category 1 and 55% of category 2 subjects showed progression to complicated pneumoconiosis after 1 decade, and 6% (4 of 64) of category 1 and 6% (5 of 77) of category 2 subjects progressed to complicated pneumoconiosis during 2 decades. Conclusion The progression of pneumoconiosis was observed after the cessation of dust exposure, especially during the first 10 years.

引用

页码：1949 / 1956

页数：8

共 27 条

[1] SPONTANEOUS AND STIMULATED RELEASE OF TUMOR NECROSIS FACTOR-ALPHA (TNF) FROM BLOOD MONOCYTES OF MINERS WITH COAL-WORKERS PNEUMOCONIOSIS [J].