Fabrication of fluorescent nanoparticles based on AIE luminogens (AIE dots) and their applications in bioimaging

被引：209

作者：

Chen, Sijie ^{[1
,2
,3
,4
]}

Wang, Hong ^{[1
,2
]}

Hong, Yuning ^{[3
]}

Tang, Ben Zhong ^{[1
,2
,5
,6
]}

机构：

[1] HKUST, Chinese Natl Engn Res Ctr Tissue Restorat & Recon, Inst Mol Funct Mat,Hong Kong Branch, Div Biomed Engn,Dept Chem,Inst Adv Study,Div Life, Kowloon, Hong Kong, Peoples R China

[2] HKUST, State Key Lab Mol Neurosci, Kowloon, Hong Kong, Peoples R China

[3] Univ Melbourne, Sch Chem, Parkville, Vic 3000, Australia

[4] Karolinsika Inst, Dept Med Biochem & Biophys, Res Div Biomat & Regenerat Med, SE-17177 Stockholm, Sweden

[5] HKUST, Shenzhen Res Inst, 9 Yuexing 1st RD,South Area,Hitech Pk Nanshan, Shenzhen 518057, Peoples R China

[6] SCUT, State Key Lab Luminescent Mat & Devices, SCUT HKUST Joint Res Lab, Guangdong Innovat Res Team, Guangzhou 510640, Guangdong, Peoples R China

来源：

MATERIALS HORIZONS | 2016年 / 3卷 / 04期

关键词：

AGGREGATION-INDUCED EMISSION; ORGANIC DOTS; SILICA NANOPARTICLES; BIOLOGICAL APPLICATIONS; QUANTUM DOTS; IN-VITRO; CELL; MICROSCOPY; PROBES; BIOPROBES;

D O I：

10.1039/c6mh00060f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Fluorescent nanoparticles (NPs) represent a new group of contrast agents for bioimaging. One of the challenging problems in this area is to fabricate fluorescent NPs with improved brightness, photostability and biocompatibility. The recently discovered aggregation-induced emission (AIE) luminogens, which exhibit enhanced emission upon aggregate formation, may circumvent these problems. Incorporating AIE fluorophores into the NP platform results in AIE dots with greatly enhanced fluorescence efficiency and superior photostability. In this review, we will summarize our effort in the last five years on the fabrication of AIE dots and their applications in bioimaging.

引用

页码：283 / 293

页数：11

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