Development of an anti-HIV vaccine eliciting broadly neutralizing antibodies

被引：22
|
作者：
Ahmed, Yousuf [1 ]
Tian, Meijuan [1 ]
Gao, Yong [1 ]
机构：
[1] Univ Western Ontario, Dept Microbiol & Immunol, Schulich Sch Med & Dent, London, ON, Canada
来源：
AIDS RESEARCH AND THERAPY | 2017年 / 14卷
关键词：
HIV-1; Diversity; Broadly neutralizing antibody; Polyvalent vaccine; B cell maturation; HUMAN-IMMUNODEFICIENCY-VIRUS; POTENT NEUTRALIZATION; ENVELOPE GLYCOPROTEIN; RHESUS-MONKEYS; SUBTYPE-B; INFECTION; RESPONSES; PROTECTION; SELECTION; IDENTIFICATION;
D O I：
10.1186/s12981-017-0178-3
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The extreme HIV diversity posts a great challenge on development of an effective anti-HIV vaccine. To solve this problem, it is crucial to discover an appropriate immunogens and strategies that are able to prevent the transmission of the diverse viruses that are circulating in the world. Even though there have been a number of broadly neutralizing anti-HIV antibodies (bNAbs) been discovered in recent years, induction of such antibodies to date has only been observed in HIV-1 infection. Here, in this mini review, we review the progress in development of HIV vaccine in eliciting broad immune response, especially production of bNAbs, discuss possible strategies, such as polyvalent sequential vaccination, that facilitates B cell maturation leading to bNAb response.
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页数：6
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