Galactomannan from Antrodia cinnamomea Enhances the Phagocytic Activity of Macrophages

被引：23
|
作者：
Perera, Namal [1 ,2 ,3 ,4 ]
Yang, Feng-Ling [1 ]
Chang, Ching-Ming [1 ]
Lu, Yueh-Tung [7 ]
Zhan, Shih-Hao [1 ]
Tsai, Yi-Ting [5 ]
Hsieh, Jung-Feng [5 ]
Li, Lan-Hui [6 ]
Hua, Kuo-Feng [7 ,8 ]
Wu, Shih-Hsiung [1 ,2 ]
机构：
[1] Acad Sinica, Inst Biol Chem, Taipei, Taiwan
[2] Acad Sinica, Taiwan Int Grad Program, Chem Biol & Mol Biophys Program, Taipei, Taiwan
[3] Natl Tsing Hua Univ, Dept Chem, Hsinchu, Taiwan
[4] Sabaragamuwa Univ, Fac Appl Sci, Belihuloya 70140, Sri Lanka
[5] Fu Jen Catholic Univ, Dept Food Sci, Taipei, Taiwan
[6] Taipei City Hosp, Kunming Branch, Dept Lab, Taipei, Taiwan
[7] Natl Ilan Univ, Dept Biotechnol & Anim Sci, Ilan, Taiwan
[8] Tri Serv Gen Hosp, Natl Def Med Ctr, Dept Pathol, Taipei, Taiwan
来源：
ORGANIC LETTERS | 2017年 / 19卷 / 13期
关键词：
NMR-SPECTROSCOPY; POLYSACCHARIDES;
D O I：
10.1021/acs.orglett.7b01468
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Galactomannan with an octasaccharide-repeating unit (ACP) was isolated from Taiwan medicinal mushroom Antrodia cinnamomea, and its chemical structure was determined herein. ACP significantly enhanced the phagocytosis and bactericidal activity of J774A.1 murine macrophages against Escherichia coli, with prospects for developing a new immunomodulatory compound or adjuvant in immunotherapy and vaccination.
引用
收藏
页码：3486 / 3489
页数：4
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