Engineering dendritic cell vaccines to improve cancer immunotherapy

被引：371

作者：

Perez, Caleb R. ^{[1
]}

De Palma, Michele ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Swiss Inst Expt Canc Res ISREC, Sch Life Sci, CH-1015 Lausanne, Switzerland

来源：

NATURE COMMUNICATIONS | 2019年 / 10卷 / 1期

基金：

欧洲研究理事会;

关键词：

KINASE; 3; LIGAND; CROSS-PRESENTATION; LYMPH-NODES; IN-VITRO; ANTIGEN-PRESENTATION; MELANOMA PATIENTS; HUMAN BLOOD; IFN-GAMMA; CD8(+); RESPONSES;

D O I：

10.1038/s41467-019-13368-y

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

At the interface between the innate and adaptive immune system, dendritic cells (DCs) play key roles in tumour immunity and hold a hitherto unrealized potential for cancer immunotherapy. Here we review the role of distinct DC subsets in the tumour microenvironment, with special emphasis on conventional type 1 DCs. Integrating new knowledge of DC biology and advancements in cell engineering, we provide a blueprint for the rational design of optimized DC vaccines for personalized cancer medicine.

引用

页数：10

共 105 条

[1] Critical role for Sec22b-dependent antigen cross-presentation in antitumor immunity [J].

Alloatti, Andres ;

Rookhuizen, Derek C. ;

Joannas, Leonel ;

Carpier, Jean-Marie ;

Iborra, Salvador ;

Magalhaes, Joao G. ;

Yatim, Nader ;

Kozik, Patrycja ;

Sancho, David ;

Albert, Matthew L. ;

Amigorena, Sebastian .

JOURNAL OF EXPERIMENTAL MEDICINE, 2017, 214 (08) :2231-2241

[2] Plasmacytoid Dendritic Cells Support Melanoma Progression by Promoting Th2 and Regulatory Immunity through OX40L and ICOSL [J].

Aspord, Caroline ;

Leccia, Marie-Therese ;

Charles, Julie ;

Plumas, Joel .

CANCER IMMUNOLOGY RESEARCH, 2013, 1 (06) :402-415

[3] Suppression of microRNA activity amplifies IFN-γ-induced macrophage activation and promotes anti-tumour immunity [J].

Baer, Caroline ;

Squadrito, Mario Leonardo ;

Laoui, Damya ;

Thompson, Danielle ;

Hansen, Sarah K. ;

Kiialainen, Anna ;

Hoves, Sabine ;

Ries, Carola H. ;

Ooi, Chia-Huey ;

De Palma, Michele .

NATURE CELL BIOLOGY, 2016, 18 (07) :790-+

[4] Large-Scale Human Dendritic Cell Differentiation Revealing Notch-Dependent Lineage Bifurcation and Heterogeneity [J].

Balan, Sreekumar ;

Arnold-Schrauf, Catharina ;

Abbas, Abdenour ;

Couespel, Norbert ;

Savoret, Juliette ;

Imperatore, Francesco ;

Villani, Alexandra-Chloe ;

Thien-Phong Vu Manh ;

Bhardwaj, Nina ;

Dalod, Marc .

CELL REPORTS, 2018, 24 (07) :1902-+

[5] Human XCR1+ Dendritic Cells Derived In Vitro from CD34+ Progenitors Closely Resemble Blood Dendritic Cells, Including Their Adjuvant Responsiveness, Contrary to Monocyte-Derived Dendritic Cells [J].

Balan, Sreekumar ;

Ollion, Vincent ;

Colletti, Nicholas ;

Chelbi, Rabie ;

Montanana-Sanchis, Frederic ;

Liu, Hong ;

Thien-Phong Vu Manh ;

Sanchez, Cindy ;

Savoret, Juliette ;

Perrot, Ivan ;

Doffin, Anne-Claire ;

Fossum, Even ;

Bechlian, Didier ;

Chabannon, Christian ;

Bogen, Bjarne ;

Asselin-Paturel, Carine ;

Shaw, Michael ;

Soos, Timothy ;

Caux, Christophe ;

Valladeau-Guilemond, Jenny ;

Dalod, Marc .

JOURNAL OF IMMUNOLOGY, 2014, 193 (04) :1622-1635

[6] A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments [J].

Barry, Kevin C. ;

Hsu, Joy ;

Broz, Miranda L. ;

Cueto, Francisco J. ;

Binnewies, Mikhail ;

Combes, Alexis J. ;

Nelson, Amanda E. ;

Loo, Kimberly ;

Kumar, Raj ;

Rosenblum, Michael D. ;

Alvarado, Michael D. ;

Wolf, Denise M. ;

Bogunovic, Dusan ;

Bhardwaj, Nina ;

Daud, Adil, I ;

Ha, Patrick K. ;

Ryan, William R. ;

Pollack, Joshua L. ;

Samad, Bushra ;

Asthana, Saurabh ;

Chan, Vincent ;

Krummel, Matthew F. .

NATURE MEDICINE, 2018, 24 (08) :1178-1191

[7] Enhancing Dendritic Cell Therapy in Solid Tumors with Immunomodulating Conventional Treatment [J].

Belderbos, Robert A. ;

Aerts, Joachim G. J., V ;

Vroman, Heleen .

MOLECULAR THERAPY-ONCOLYTICS, 2019, 13 :67-81

[8] Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity [J].

Binnewies, Mikhail ;

Mujal, Adriana M. ;

Pollack, Joshua L. ;

Combes, Alexis J. ;

Hardison, Emily A. ;

Barry, Kevin C. ;

Tsui, Jessica ;

Ruhland, Megan K. ;

Kersten, Kelly ;

Abushawish, Marwan A. ;

Spasic, Marko ;

Giurintano, Jonathan P. ;

Chan, Vincent ;

Daud, Adil, I ;

Ha, Patrick ;

Ye, Chun J. ;

Roberts, Edward W. ;

Krummel, Matthew F. .

CELL, 2019, 177 (03) :556-+

[9] NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control [J].

Boettcher, Jan P. ;

Bonavita, Eduardo ;

Chakravarty, Probir ;

Blees, Hanna ;

Cabeza-Cabrerizo, Mar ;

Sammicheli, Stefano ;

Rogers, Neil C. ;

Sahai, Erik ;

Zelenay, Santiago ;

Reis e Sousa, Caetano .

CELL, 2018, 172 (05) :1022-+

[10] Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance [J].

Bonifaz, L ;

Bonnyay, D ;

Mahnke, K ;

Rivera, M ;

Nussenzweig, MC ;

Steinman, RM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (12) :1627-1638

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