Role of Chimeric Antigen Receptor T Cell Therapy in Glioblastoma Multiforme

被引：3

作者：

Jindal, Vishal ^{[1
]}

机构：

[1] St Vincent Hosp, Dept Internal Med, 123 Summer St, Worcester, MA 01608 USA

来源：

MOLECULAR NEUROBIOLOGY | 2018年 / 55卷 / 11期

关键词：

Glioblastoma multiforme; Chimeric antigen receptor; Adoptive T cell therapy; EXPERIMENTAL BRAIN METASTASES; SUSTAINED REMISSIONS; MALIGNANT-CELLS; B-CELL; BARRIER; CD4(+); INTERLEUKIN-13; IMMUNOTHERAPY; PERMEABILITY; CHEMOTHERAPY;

D O I：

10.1007/s12035-018-0978-z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Glioblastoma multiforme (GBM) is the most common primary malignant cancer of brain, which is extremely aggressive and carries a dreadful prognosis. Current treatment protocol runs around radiotherapy, surgical resection, and temozolomide with median overall survival of around 12-15months. Due to its heterogeneity and mutational load, immunotherapy with chimeric antigen receptor (CAR) T cell therapy can be a promising treatment option for recurrent glioblastoma. Initial phase 1 studies have shown that this therapy is safe without dose-limiting side effects and it also has a better clinical outcome. Therefore, CAR T cell therapy can be a great future tool in our armamentarium to treat advanced GBM. In this article, we have explained the structure, mechanism of action, and rationale of CAR T cell therapy in GBM; we also discussed various antigenic targets and clinical outcome of initial studies of this novel therapy.

引用

页码：8236 / 8242

页数：7

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