Sildenafil selectively inhibits acute pulmonary embolism-induced pulmonary hypertension

被引:45
作者
Dias-Junior, CA
Vieira, TF
Moreno, H
Evora, PR
Tanus-Santos, JE
机构
[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Pharmacol, BR-14049900 Ribeirao Preto, SP, Brazil
[2] State Univ Campinas, Dept Pharmacol, Campinas, SP, Brazil
[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Div Expt Surg, Ribeirao Preto, SP, Brazil
基金
巴西圣保罗研究基金会;
关键词
sildenafil; pulmonary embolism; pulmonary hypertension; pharmacology; phosphodiesterase inhibitors;
D O I
10.1016/j.pupt.2004.11.010
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Selective pulmonary vasodilators attenuate acute pulmonary embolism (APE)-induced pulmonary hypertension. We examined the effects of intravenous sildenafil on the hemodynamic and respiratory changes caused by APE in anesthetized dogs. Sham operated animals (n = 3) received only saline infusions. APE was induced by intravenous injections of microspheres in amounts adjusted to increase mean pulmonary artery pressures (MPAP) by 20 mmHg. Hemodynamic evaluation was performed and arterial blood samples were drawn for blood.-as analysis at baseline, 15 and 30 min after APE was induced, and then 15, 30, and 45 min after the sildenafil infusion (1 mg kg(-1) infused intravenously in 15 min followed by 0.3 mg kg(-1)h(-1) for 30 min) started in the Sildenafil group (n = 7), or saline infusion started in the control group (n = 8). APE induced sustained pulmonary hypertension and 325% increase in pulmonary vascular resistance index (PVRI) without significant changes in the other hemodynamic parameters. While the animals in the control group showed no further changes in MPAP and PVRI, a significant decrease in MPAP and PVRI (-25 and -45%, respectively; P < 0.05 both) was observed with sildenafil. No significant changes in the other hemodymamic parameters were observed in both groups. APE decreased PaO2, whereas sildenafil attenuated the decrease in PaO2 (P < 0.05). We conclude that intravenous sildenafil can selectively attenuate the increases in MPAP and PVRI after APE. (C) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:181 / 186
页数:6
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