Synthesis of 4-trifluoromethyl-2H-chromenes via the reaction of 2-(trifluoroacetyl)phenols with vinyltriphenylphosphonium chloride

被引：1

作者：

Golubev, Alexander S. ^{[1
]}

Ostapchuk, Petr N. ^{[1
,3
]}

Strelkova, Tatiana, V ^{[1
]}

Kagramanov, Nikolai D. ^{[1
]}

Suponitsky, Kyrill Yu ^{[1
,2
]}

Takazova, Rina U. ^{[1
]}

Chkanikov, Nikolai D. ^{[1
]}

机构：

[1] Russian Acad Sci, AN Nesmeyanov Inst Organoelement Cpds, Vavilov St 28,GSP 1, Moscow, Russia

[2] GV Pleklzanov Russian Univ Econ, 36 Stremyannyi Line, Moscow 117997, Russia

[3] Russian Acad Sci, ND Zelinsky Inst Organ Chem, 47 Leninsky Prosp, Moscow 119991, Russia

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2022年 / 20卷 / 34期

关键词：

CYCLOOXYGENASE-2; INHIBITORS; ALLYLIC ALCOHOLS; ROUTE; SALICYLALDEHYDES; DERIVATIVES; CHROMENES; EFFICIENT; FLUORINE; ANALOGS; KETONES;

D O I：

10.1039/d2ob01177h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Substituted on the benzene ring 4-CF3-2H-chromenes have been prepared from substituted 2-(trifluoroacetyl)phenols and vinyltriphenylphosphonium chloride according to the Schweizer protocol in moderate to excellent yields. The influence of the type and the position of aromatic ring substituents on yields of 4-CF3-2H-chromenes have been investigated. It has been shown that 4-CF3-2H-chromenes are convenient precursors to 4-CF3-coumarins.

引用

页码：6809 / 6820

页数：12

共 52 条

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