Application of nanosized Fe3O4 in anticancer drug carriers with target-orientation and sustained-release properties

被引:59
作者
Lin, Ben-Lan [1 ]
Shen, Xiao-Dong [1 ]
Cui, Sheng [1 ]
机构
[1] Coll Mat Sci & Technol, Nanjing 210009, Peoples R China
关键词
D O I
10.1088/1748-6041/2/2/011
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The purpose of this study was to prepare human serum albumin (HSA) microspheres with Fe3O4 magnetic nanoparticles for tumor target therapy. Fe3O4 was obtained by liquid-phase coprecipitation; HSA-coated magnetic particles were attained by solidification at high temperature. The result was that nanosized Fe3O4 is a cubic crystal by XRD and the average size is 18.7 nm; the average size of HSA-coated magnetic particles is 341 nm. Fe3O4 magnetic nanoparticles coated with HSA can be used for targeted-drug carriers with target-orientation and sustained-release properties.
引用
收藏
页码:132 / 134
页数:3
相关论文
共 6 条
[1]  
ARTURO M, 1993, J COLLOID INTERF SCI, V158, P446
[2]  
BENLAN L, 2005, CHIN HOSP PHARM J, V25, P424
[3]  
GUOBIN W, 2004, J HUAZHONG U SCI TEC, V4, P452
[4]   Modifying the surface properties of superparamagnetic iron oxide nanoparticles through a sol-gel approach [J].
Lu, Y ;
Yin, YD ;
Mayers, BT ;
Xia, YN .
NANO LETTERS, 2002, 2 (03) :183-186
[5]  
YONG L, 2001, J BIOMED ENG, V18, P169
[6]   Preparation and characterization of core-shell monodispersed magnetic silica microspheres [J].
Zhu, YH ;
Da, H ;
Yang, XL ;
Hu, Y .
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2003, 231 (1-3) :123-129