A Retrospective Experience of Helicobacter pylori Histology in a Large Sample of Subjects in Northern Italy

被引:4
作者
Ribaldone, Davide Giuseppe [1 ]
Zurlo, Carlo [1 ]
Fagoonee, Sharmila [2 ]
Rosso, Chiara [1 ]
Armandi, Angelo [1 ]
Caviglia, Gian Paolo [1 ]
Saracco, Giorgio Maria [1 ]
Pellicano, Rinaldo [3 ]
机构
[1] Univ Torino, Dept Med Sci, Div Gastroenterol, I-10124 Turin, Italy
[2] Mol Biotechnol Ctr, Inst Biostruct & Bioimaging CNR, I-10126 Turin, Italy
[3] Citta Salute & Sci Torino, Gastroenterol U, Dept Gen & Specialist Med, Cso Bramante 88, I-10126 Turin, Italy
来源
LIFE-BASEL | 2021年 / 11卷 / 07期
关键词
fundus; body; corpus; antrum; duodenum; EPIDEMIOLOGY; CANCER;
D O I
10.3390/life11070650
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Updated data about the prevalence of Helicobacter pylori (H. pylori) and its correlation with histological results are scarce. The aim of our study was to provide current data on the impact of H. pylori in a third-level endoscopy service. We performed a large, retrospective study analyzing the results of all histological samples of gastroscopy from the year 2019. In total, 1512 subjects were included. The prevalence of H. pylori was 16.8%. A significant difference between the prevalence in subjects born in Italy and those from eastern Europe, south America, or Africa was found (p < 0.0001, p = 0.006, and p = 0.0006, respectively). An association was found between H. pylori and active superficial gastritis (p < 0.0001). Current H. pylori and/or a previous finding of H. pylori was related to antral atrophy (p < 0.0001). Fifteen patients had low-grade dysplasia. There were no statistically significant associations with current or past H. pylori infection. One patient presented gastric cardia adenocarcinoma with regular gastric mucosa. One patient, H. pylori positive, was diagnosed with gastric signet ring cell adenocarcinoma in a setting of diffuse atrophy, without metaplasia.. Our study provides updated, solid (biopsy diagnosis and large population) data on the prevalence of H. pylori infection in a representative region of southern Europe.
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