Vaccine-induced host responses against very virulent Marek's disease virus infection in the lungs of chickens

被引：23

作者：

Haq, Kamran ^{[1
]}

Abdul-Careem, Mohamed Faizal ^{[2
]}

Shanmuganthan, Sangitha ^{[1
]}

Thanthrige-Don, Niroshan ^{[1
]}

Read, Leah R. ^{[1
]}

Sharif, Shayan ^{[1
]}

机构：

[1] Univ Guelph, Ontario Vet Coll, Dept Pathobiol, Guelph, ON N1G 2W1, Canada

[2] McMaster Univ, Dept Pathol & Mol Med, Ctr Gene Therapeut, Hamilton, ON L8N 3Z5, Canada

来源：

VACCINE | 2010年 / 28卷 / 34期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Marek's disease virus; Herpesvirus of turkeys; Lung; Cell-mediated immune response; CD4+T cell; CD8+T cell; Cytokine; CYTOKINE GENE-EXPRESSION; TURKEY HERPESVIRUS; CELL; RESISTANCE; MDV; PATHOGENESIS; TISSUES; MODEL; ESTABLISHMENT; REPLICATION;

D O I：

10.1016/j.vaccine.2010.06.036

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The aim of this study was to investigate the kinetics of virus replication and cellular responses in the lungs following infection with Marek's disease virus (MDV) and/or vaccination with herpesvirus of turkey (HVT) via the respiratory route. Chickens vaccinated with HVT and challenged with MDV had a higher accumulation of MDV and HVT genomes in the lungs compared to the chickens that received HVT or MDV alone. This increase in virus load was associated with augmented expression of interferon (IFN)-gamma and interleukin (IL)-10, and increased T cell infiltration. These findings shed more light on the immunological events that occur in the lungs after vaccination or infection with MDV. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：5565 / 5572

页数：8

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