Iron oxide nanoparticle core-shell magnetic microspheres: Applications toward targeted drug delivery

被引：35

作者：

Ayyanaar, Srinivasan ^{[1
]}

Kesavan, Mookkandi Palsamy ^{[2
]}

Balachandran, Chandrasekar ^{[3
]}

Rasala, Swetha ^{[4
]}

Rameshkumar, Perumal ^{[5
]}

Aoki, Shin ^{[3
,6
]}

Rajesh, Jegathalaprathaban ^{[7
]}

Webster, Thomas J. ^{[8
]}

Rajagopal, Gurusamy ^{[1
]}

机构：

[1] Chikkanna Govt Arts Coll, PG & Res Dept Chem, Tiruppur, Tamil Nadu, India

[2] Hajee Karutha Rowther Howdia Coll, Dept Chem, Uthamapalayam, Tamil Nadu, India

[3] Tokyo Univ Sci, Fac Pharmaceut Sci, Noda, Chiba, Japan

[4] Natl Univ Ireland Galway, Ctr Res Med Devices CURAM, Galway, Ireland

[5] Kalasalingam Acad Res & Educ, Dept Chem, Krishnankoil, Tamil Nadu, India

[6] Tokyo Univ Sci, Res Inst Sci & Technol, Noda, Chiba, Japan

[7] Mohamed Sathak Engn Coll, Chem Res Ctr, Kilakarai, Tamil Nadu, India

[8] Northeastern Univ, Dept Chem Engn, Boston, MA 02115 USA

来源：

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2020年 / 24卷

关键词：

Poly(D; L-lactide-co-glycolic acid); Lecithin; Magnetic core microsphere; Cytotoxicity; Targeted drug delivery; OXIDATIVE STRESS; CANCER-CELLS; ROS; MICROCAPSULES; ADSORPTION; EFFICIENCY; COMPLEXES; POLYMERS; REMOVAL; RELEASE;

D O I：

10.1016/j.nano.2019.102134

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

This study describes a sensitive reactive oxygen species (ROS)-responsive lecithin (LEC) incorporated iron oxide nanoparticle (Fe3O4 NP) system with potent anti-inflammatory properties and even more so when the antioxidant drug curcumin (CUR) is encapsulated in the PLGA hybrid magnetic microsphere system (Fe3O4@LEC-CUR-PLGA-MMS). The delivery system is responsive to ROS including an H2O2 environment to release the payload (CUR) drug. Greater cytotoxicity properties were observed in the presence of Fe3O4@LEC-CUR-PLGA-MMS against A549 and HeLa S3 cells with IC50 values after 24 h of 10 and 12 mu g/mL and 10 and 20 mu g/mL, respectively. The present Fe3O4@LEC-CUR-PLGA-MMS system demonstrated much better in vitro cytotoxicity, cellular morphological changes and moreover an ability to limit colony formation for A549 and HeLa S3 cancer cell lines than non-cancerous cells, and thus, should be further studied for a wide range of medical applications. (C) 2019 Elsevier Inc. All rights reserved.

引用

页数：11

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