Anti-tumor activity of the farnesyl-protein transferase inhibitors arteminolides, isolated from Artemisa

被引：47
作者：
Lee, SH
Lee, MY
Kang, HM
Han, DC
Son, KH
Yang, DC
Sung, ND
Lee, CW
Kim, HM
Kwon, BM
机构：
[1] Korea Res Inst Biosci & Biotechnol, Taejon 305600, South Korea
[2] Chungbuk Natl Univ, Sch Life Sci, Coll Nat Sci, Chonju 360763, South Korea
[3] Chungnam Natl Univ, Coll Agr, Taejon 305764, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2003年 / 11卷 / 21期
关键词：
D O I：
10.1016/j.bmc.2003.08.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
M embers of the Artemisia genus are important medicinal plants found throughout the world. Arteminolides A-D (1-4), isolated from the aerial parts of Artemisia, have an inhibitory activity on farnesyl-protein transferase (FPTase; EC 2.5.1.29) in in vitro assay. This study was carried out with the purpose of validating anti-tumor effects of the compounds in human tumor cells and mouse xenograft model. The arteminolides inhibited tumor cell growth in a dose-dependent manner. Furthermore, arteminolide C (3) blocked in vivo growth of human colon and lung tumor xenograft without the loss of body weight in nude mice. (C) 2003 Elsevier Ltd. All rights reserved.
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收藏
页码：4545 / 4549
页数：5
相关论文
共 13 条
[1]   The potential of farnesyltransferase inhibitors as cancer chemotherapeutics [J].
Gibbs, JB ;
Oliff, A .
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1997, 37 :143-166
[2]   The influence of glutathione and cysteine levels on the cytotoxicity of helenanolide type sesquiterpene lactones against KB cells [J].
Heilmann, J ;
Wasescha, MR ;
Schmidt, TJ .
BIOORGANIC & MEDICINAL CHEMISTRY, 2001, 9 (08) :2189-2194
[3]  
Kim HM, 1996, J PHARMACOL TOXICOL, V36, P163
[4]   New sesquiterpene-monoterpene lactone, artemisolide, isolated from Artemisia argyi [J].
Kim, JH ;
Kim, HK ;
Jeon, SB ;
Son, KH ;
Kim, EH ;
Kang, SK ;
Sung, ND ;
Kwon, BM .
TETRAHEDRON LETTERS, 2002, 43 (35) :6205-6208
[5]   Arteminolides B, C, and D, new inhibitors of farnesyl protein transferase from Artemisia argyi [J].
Lee, SH ;
Kim, HK ;
Seo, JM ;
Kang, HM ;
Kim, JH ;
Son, KH ;
Lee, H ;
Kwon, BM ;
Shin, J ;
Seo, Y .
JOURNAL OF ORGANIC CHEMISTRY, 2002, 67 (22) :7670-7675
[6]  
Marco J., 1990, STUD NAT PROD CHEM, V7, P201
[7]   RECENT STUDIES ON THE ZOOPHARMACOGNOSY, PHARMACOLOGY AND NEUROTOXICOLOGY OF SESQUITERPENE LACTONES [J].
ROBLES, M ;
AREGULLIN, M ;
WEST, J ;
RODRIGUEZ, E .
PLANTA MEDICA, 1995, 61 (03) :199-203
[8]  
Schmidt TJ, 1999, CURR ORG CHEM, V3, P577
[9]   Antitumor activity of flavones isolated from Artemisia argyi [J].
Seo, JM ;
Kang, HM ;
Son, KH ;
Kim, JH ;
Lee, CW ;
Kim, HM ;
Chang, SI ;
Kwon, BM .
PLANTA MEDICA, 2003, 69 (03) :218-222
[10]   Mono- and sesquiterpenes and antifungal constituents from Artemisia species [J].
Tan, RX ;
Lu, H ;
Wolfender, JL ;
Yu, TT ;
Zheng, WF ;
Yang, L ;
Gafner, S ;
Hostettmann, K .
PLANTA MEDICA, 1999, 65 (01) :64-67
12