Synthesis and biological evaluation of some novel fused thiazolo[3,2-a]pyrimidines as potential analgesic and anti-inflammatory agents

被引：37

作者：

Khalifa, Nagy M. ^{[1
,2
]}

Al-Omar, Mohamed A. ^{[1
]}

Amr, Abd El-Galil E. ^{[1
,3
]}

Baiuomy, Ayman R. ^{[4
,5
]}

Abdel-Rahman, Rehab F. ^{[4
]}

机构：

[1] King Saud Univ, Coll Pharm, DEDC, Dept Pharmaceut Chem, Riyadh 11451, Saudi Arabia

[2] Natl Res Ctr, Dept Therapeut Chem, Pharmaceut & Drug Ind Div, Cairo 12622, Dokki, Egypt

[3] Natl Res Ctr, Appl Organ Chem Dept, Cairo 12622, Dokki, Egypt

[4] Natl Res Ctr, Dept Pharmacol, Cairo 12622, Dokki, Egypt

[5] Taif Univ, Coll Med & Med Sci, At Taif, Saudi Arabia

来源：

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2015年 / 41卷 / 02期

关键词：

thiazolopyrimidine; Biginelli compounds; anti-inflammatory; analgesic; DERIVATIVES; THIAZOLOPYRIMIDINE; PYRIMIDINE; ANTIOXIDANT; INHIBITION; ANALOGS;

D O I：

10.1134/S1068162015020090

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Some novel bicyclic thiazolopyrimidine derivatives bearing various substituents have been synthesized through one-pot three-component method. Structures of the target compounds were confirmed by elemental analysis and spectral data. Some selected members of the newly synthesized compounds were investigated for their analgesic and anti-inflammatory activities and revealed pronounced anti-inflammatory activity greater than that of indomethacin (reference drug).

引用

页码：192 / 200

页数：9

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