Kinetics and mechanism of interaction of hexaaquachromium(III) with l-Dopa in aqueous medium: comparative antiparkinsonian studies

被引：4

作者：

Baral, Dillip Kumar ^{[1
]}

Rout, Sudhanshu Sekhar ^{[2
]}

Behera, Jashoda ^{[1
]}

Si, Sudam Chandra ^{[2
]}

Mohanty, Prakash ^{[1
]}

机构：

[1] Utkal Univ, Dept Chem, Bhubaneswar 751004, Orissa, India

[2] Siksha O Anusandhan Univ, Sch Pharmacol, Dept Pharmacol, Bhubaneswar, Orissa, India

来源：

TRANSITION METAL CHEMISTRY | 2011年 / 36卷 / 02期

关键词：

HEXAAQUOCHROMIUM(III) ION; ANATION; DEPRESSION; CHROMIUM(III); COMORBIDITY; ANXIETY; ACID;

D O I：

10.1007/s11243-011-9460-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The kinetics and mechanism of the substitution reaction between [Cr(H2O)(6)](3+) and l-Dopa in aqueous medium has been studied over the range 1.8 a parts per thousand currency sign pH a parts per thousand currency sign 2.6, 1.68 x 10(-2) mol dm(-3) a parts per thousand currency sign [Dopa] a parts per thousand currency sign 5.04 x 10(-2) mol dm(-3), I = 0.1 mol dm(-3) (KNO3) at 50 A degrees C. The reaction takes place via an outer sphere association between Cr3+ and l-Dopa followed by chelation. The product was characterized by physicochemical and infrared spectroscopic methods. The antiparkinsonian activity of the product was found to be higher than that of l-Dopa.

引用

页码：231 / 236

页数：6

共 31 条

[1] A KINETIC AND EQUILIBRIUM STUDY OF THE REACTION OF GLYCINE WITH CHROMIUM(III) IN AQUEOUS-SOLUTION [J].

ABDULLAH, MA ;

BARRETT, J ;

OBRIEN, P .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1984, (08) :1647-1650

[2] KINETIC STUDIES ON FORMATION OF METAL CHELATES .2. REACTION OF HEXA-AQUO-CHROMIUM(3) ION WITH GLYCINE AND NATURE OF PRODUCT FORMED IN WEAKLY ACIDIC AQUEOUS SOLUTION [J].

BANERJEA, D ;

CHAUDHUR.SD .

JOURNAL OF INORGANIC & NUCLEAR CHEMISTRY, 1968, 30 (03) :871-&

[3]

Behera J, 2001, J INDIAN CHEM SOC, V78, P123

[4] Kinetics of formation and dissociation of the ternary complex ion (pentane-2,4-dionato)(nitrilotriacetato)chromate(III) in aqueous media [J].

Bhattacharyya, SK ;

Banerjee, R .

POLYHEDRON, 1997, 16 (24) :4217-4220

[5]

Cummings JL, 1999, INT J GERIATR PSYCH, V14, P711, DOI 10.1002/(SICI)1099-1166(199909)14:9<711::AID-GPS4>3.3.CO

[6]

2-T

[7]

Dash SC, 2006, INDIAN J CHEM A, V45, P2406

[8] Kinetics and mechanism of the reaction of aquachromium(III) with L-ascorbic acid in aqueous media [J].

Dei, JK ;

Pasupalak, NN ;

Mohanty, P .

TRANSITION METAL CHEMISTRY, 1997, 22 (05) :516-520

[9] AN ESTIMATE OF THE INCIDENCE OF DEPRESSION IN IDIOPATHIC PARKINSONS-DISEASE [J].

DOONEIEF, G ;

MIRABELLO, E ;

BELL, K ;

MARDER, K ;

STERN, Y ;

MAYEUX, R .

ARCHIVES OF NEUROLOGY, 1992, 49 (03) :305-307

[10] COMPLEX IONS OF CHROMIUM .8. MECHANISM OF REACTION OF ORGANIC ACID ANIONS WITH CHROMIUM(III) [J].

HAMM, RE ;

JOHNSON, RL ;

PERKINS, RH ;

DAVIS, RE .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1958, 80 (17) :4469-4471

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