Roles of RNA methylation by means of N6-methyladenosine (m6A) in human cancers

被引：190

作者：

Wang, Siwei ^{[1
,2
,3
,4
]}

Sun, Chunxiao ^{[5
]}

Li, Jianhua ^{[6
]}

Zhang, Erbao ^{[7
]}

Ma, Zhifei ^{[1
,2
,3
,4
]}

Xu, Weizhang ^{[1
,2
,3
,4
]}

Li, Hong

Qiu, Mantang ^{[8
]}

Xu, Youtao ^{[1
,2
,3
]}

Xia, Wenjia ^{[1
,2
,3
]}

Xu, Lin ^{[1
,2
,3
]}

Yin, Rong ^{[1
,2
,3
]}

机构：

[1] Jiangsu Canc Hosp, Dept Thorac Surg, Nanjing 210009, Jiangsu, Peoples R China

[2] Jiangsu Inst Canc Res, Nanjing 210009, Jiangsu, Peoples R China

[3] Nanjing Med Univ, Affiliated Canc Hosp, Jiangsu Key Lab Mol & Translat Canc Res, Nanjing 210009, Jiangsu, Peoples R China

[4] Nanjing Med Univ, Clin Coll 4, Nanjing 210000, Jiangsu, Peoples R China

[5] Nanjing Med Univ, Affiliated Hosp 1, Nanjing 210000, Jiangsu, Peoples R China

[6] Taizhou Peoples Hosp, Dept Pharm, Taizhou 225300, Peoples R China

[7] Nanjing Med Univ, Sch Publ Hlth, Collaborat Innovat Ctr Canc Personalized Med,Dept, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Nanjing 210000, Jiangsu, Peoples R China

[8] Peking Univ, Peoples Hosp, Dept Thorac Surg, Beijing 100044, Peoples R China

来源：

CANCER LETTERS | 2017年 / 408卷

基金：

中国国家自然科学基金;

关键词：

RNA methylation; N-6-methyladenosine; m(6)A; Human cancers; Cancer therapy; S-ADENOSYLHOMOCYSTEINE HYDROLASE; MESSENGER-RNA; DEMETHYLASE ALKBH5; NUCLEAR-RNA; GENE-EXPRESSION; HEPATOCELLULAR-CARCINOMA; CRYSTAL-STRUCTURE; SARCOMA-VIRUS; FTO GENE; MOUSE;

D O I：

10.1016/j.canlet.2017.08.030

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Reversible methylation by means of N6-methyladenosine (m(6)A) is the most prevalent internal modification in mammalian mRNA. This RNA chemical mark is created by proteins that are m(6)A "writers" and can be reversed by proteins that are m(6)A "erasers" (i.e., demethylases). Some other proteins serving as "readers" can recognize m(6)A-containing mRNA and regulate downstream molecular mechanisms accordingly. Although m(6)A bases in RNA perform critical functions in important biological processes, their roles in cancer biology and cancer stem cells remain largely unknown. In this review, we focus on the m(6)A-associated mechanisms and modification landscapes in several major malignant tumors. Global and detailed analyses were both conducted on relevant high-throughput sequencing data. Possible interventions against m(6)A demethylases are also explored in this review, which may be advantageous for the treatment of m(6)A related cancers. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：112 / 120

页数：9

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