Roles of Gut-Derived Secretory Factors in the Pathogenesis of Non-Alcoholic Fatty Liver Disease and Their Possible Clinical Applications

被引：15

作者：

Okubo, Hirofumi ^{[1
]}

Kushiyama, Akifumi ^{[2
]}

Nakatsu, Yusuke ^{[3
]}

Yamamotoya, Takeshi ^{[3
]}

Matsunaga, Yasuka ^{[4
]}

Fujishiro, Midori ^{[5
]}

Sakoda, Hideyuki ^{[6
]}

Ohno, Haruya ^{[1
]}

Yoneda, Masayasu ^{[7
]}

Asano, Tomoichiro ^{[3
]}

机构：

[1] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Mol & Internal Med, Hiroshima 7348551, Japan

[2] Asahi Life Fdn, Inst Adult Dis, Div Diabet & Metab, Tokyo 1030002, Japan

[3] Hiroshima Univ, Grad Sch Biomed Sci, Div Mol Med Sci, Dept Med Chem, Hiroshima 7348551, Japan

[4] Tulane Univ, Sch Med, Ctr Translat Res Infect & Inflammat, 6823 St Charles Ave, New Orleans, LA 70118 USA

[5] Nihon Univ, Div Diabet & Metab Dis, Sch Med, Tokyo 1738610, Japan

[6] Univ Miyazaki, Dept Internal Med, Fac Med, Div Neurol Respirol Endocrinol & Metab, Miyazaki 8891692, Japan

[7] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Prevent Med Diabet & Lifestyle Related Dis, Hiroshima 7348551, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 10期

基金：

日本学术振兴会;

关键词：

non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; gut-liver axis; resistin like molecule beta; glucagon-like peptide-1; glucagon-like peptide-2; fibroblast growth factor 19; neurotensin; GLUCAGON-LIKE PEPTIDE-2; RESISTIN-LIKE-MOLECULE; BILE-ACID SYNTHESIS; SHORT-BOWEL SYNDROME; RECEPTOR EXPRESSION; RELM-BETA; CARDIOVASCULAR-DISEASE; HEPATIC STEATOSIS; TRANSGENIC MICE; METABOLIC-RATE;

D O I：

10.3390/ijms19103064

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The rising prevalence of non-alcoholic fatty liver disease (NAFLD) parallels the global increase in the number of people diagnosed with obesity and metabolic syndrome. The gut-liver axis (GLA) plays an important role in the pathogenesis of NAFLD/non-alcoholic steatohepatitis (NASH). In this review, we discuss the clinical significance and underlying mechanisms of action of gut-derived secretory factors in NAFLD/NASH, focusing on recent human studies. Several studies have identified potential causal associations between gut-derived secretory factors and NAFLD/NASH, as well as the underlying mechanisms. The effects of gut-derived hormone-associated drugs, such as glucagon-like peptide-1 analog and recombinant variant of fibroblast growth factor 19, and other new treatment strategies for NAFLD/NASH have also been reported. A growing body of evidence highlights the role of GLA in the pathogenesis of NAFLD/NASH. Larger and longitudinal studies as well as translational research are expected to provide additional insights into the role of gut-derived secretory factors in the pathogenesis of NAFLD/NASH, possibly providing novel markers and therapeutic targets in patients with NAFLD/NASH.

引用

页数：18