Evidence for a histaminergic system in the human testis

被引：33
作者：
Albrecht, M
Frungieri, MB
Gonzalez-Calvar, S
Meineke, V
Köhn, FM
Mayerhofer, A
机构：
[1] Univ Munich, Anat Inst Biederstein, D-80802 Munich, Germany
[2] Inst Biol & Med Expt, RA-1428 Buenos Aires, DF, Argentina
[3] Sanitatsakad Bundeswehr, Inst Strahlenbiol, Munich, Germany
[4] Tech Univ Munich, Dept Dermatol & Allergy, Munich, Germany
来源：
FERTILITY AND STERILITY | 2005年 / 83卷 / 04期
关键词：
D O I：
10.1016/j.fertnstert.2004.12.002
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
The complete lack of information about mast cells as a source of histamine and potential target cells for histamine in human testes prompted us to investigate these issues in testes of fertile and infertile patients using a combination of laser microdissection, reverse transcription-polymerase chain reaction (RT-PCR), and immunohistochemistry. We show for the first time the expression of the rate-limiting enzyme in histamine synthesis-histidine decarboxylase-by human testicular mast cells and the expression of the histamine (H) receptors 1 (H1) and 2 (H2) by germinal, interstitial, and peritubular cells in the testes of fertile and infertile patients. (c) 2005 by American Society for Reproductive Medicine.
引用
收藏
页码：1060 / 1063
页数：4
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