Synthesis and antitumor activity evaluation of novel oleanolic acid derivatives

被引：21

作者：

Meng, Yan-Qiu ^{[1
]}

Zhao, Yu-Wei ^{[1
]}

Kuai, Zhen-Yu ^{[1
]}

Liu, Li-Wei ^{[1
]}

Li, Wei ^{[1
]}

机构：

[1] Shenyang Univ Chem Technol, Dept Pharmaceut Engn, Shenyang 110142, Liaoning, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2017年 / 19卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Oleanolic acid; pentacyclic triterpenoid; antitumor activity; OLEANANE-TYPE TRITERPENES; HCV ENTRY INHIBITORS; OSTEOCLAST FORMATION;

D O I：

10.1080/10286020.2017.1283310

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ten novel oleanolic acid (OA) derivatives were synthesized through modifications at positions of A ring and C-28. Inhibitory activities of the oleanolic acid derivatives against SGC7901 and A549 cell lines were evaluated and confirmed by the tetrazolium bromidesalt (MTT) assay. The lab results revealed that all these compounds displayed some antitumor activity against SGC-7901 and A-549 cell lines. Among them, II4 and II5 exhibited excellent antitumor activities against SGC7901 cells and A549 cells, compared with gefitinib. Molecular docking studies have shown that compounds II4 and II5 produce potent antitumor activities by interacting with C-kit receptor through hydrogen bonds and hydrophobic bonds.

引用

页码：1000 / 1010

页数：11

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