Inflammation, HIF-1, and the Epigenetics That Follows

被引：30

作者：

Brigati, Claudio ^{[1
]}

Banelli, Barbara ^{[1
]}

di Vinci, Angela ^{[1
]}

Casciano, Ida ^{[1
]}

Allemanni, Giorgio ^{[1
]}

Forlani, Alessandra ^{[1
]}

Borzi, Luana ^{[1
]}

Romani, Andmassimo ^{[1
]}

机构：

[1] Natl Inst Canc Res, Tumor Genet Lab, I-16132 Genoa, Italy

来源：

MEDIATORS OF INFLAMMATION | 2010年 / 2010卷

关键词：

HYPOXIA-INDUCIBLE FACTOR; HISTONE METHYLATION; RNA INTERFERENCE; H3K9; METHYLATION; DEMETHYLASES; CANCER; CELLS; REPRESSION; CHROMATIN;

D O I：

10.1155/2010/263914

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We summarize recent findings linking inflammatory hypoxia to chromatin modifications, in particular to repressive histone signatures. We focus on the role of Hypoxia-Induced Factor-1 in promoting the activity of specific histone demethylases thus deeply modifying chromatin configuration. The consequences of these changes are depicted in terms of gene expression and cellular phenotypes. We finally integrate available data to introduce novel speculations on the relationship between inflammation, histones, and DNA function and integrity.

引用

页数：5

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