Protective effect of D-pinitol on the experimental spinal cord injury in rats

被引：10
|
作者：
An, Yan [1 ]
Li, Jianing [1 ]
Liu, Yajun [1 ]
Fan, Mingxing [1 ]
Tian, Wei [1 ]
机构：
[1] Beijing Jishuitan Hosp, Dept Spine Surg, Beijing 100035, Peoples R China
来源：
METABOLIC BRAIN DISEASE | 2020年 / 35卷 / 03期
关键词：
D-pinitol; Oxidative stress; Inflammation; Apoptosis; PATHOPHYSIOLOGY; EPIDEMIOLOGY; APOPTOSIS;
D O I：
10.1007/s11011-020-00537-y
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Spinal cord injury (SCI) is the major cause of the spinal damage affecting motor and sensory function. Thus, the present study was conducted to investigate the effect of D-pinitol (PN) on spinal cord injury in rats. The PN showed to recover motor function near to normal via modulating oxidative stress, inflammatory response and cellular apoptosis in SCI rats. PN also causes modulation of Bcl2 family proteins and reduces the level of NF-& x138;B and LOX-1 in dose dependent manner. The PN causes reduction of NLRP3, TNF-alpha and iNOS, with increase in caspase-1 together with modulation of MAPK mediators. It has been suggested that, D-pinitol exert protective action against SCI via inhibition of apoptosis, inflammation and oxidative stress, via modulating Bcl-2 genes and MAPK pathway.
引用
收藏
页码：473 / 482
页数：10
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