Hyperpolarized helium-3 magnetic resonance lung imaging of non-sedated infants and young children: a proof-of-concept study

被引：30

作者：

Altes, Talissa A. ^{[1
,2
]}

Meyer, Craig H. ^{[2
,3
]}

Mata, Jaime F. ^{[2
]}

Froh, Deborah K. ^{[4
]}

Paget-Brown, Alix ^{[4
]}

Teague, W. Gerald ^{[4
]}

Fain, Sean B. ^{[5
]}

de Lange, Eduard E. ^{[2
]}

Ruppert, Kai ^{[7
]}

Botfield, Martyn C. ^{[6
]}

Johnson, Mac A. ^{[6
]}

Mugler, John. P., III ^{[2
,3
]}

机构：

[1] Univ Missouri, Dept Radiol, Columbia, MO USA

[2] Univ Virginia, Dept Radiol & Med Imaging, Charlottesville, VA USA

[3] Univ Virginia, Dept Biomed Engn, Charlottesville, VA USA

[4] Univ Virginia, Dept Pediat, Charlottesville, VA USA

[5] Univ Wisconsin, Dept Med Phys & Radiol, Madison, WI USA

[6] Vertex Pharmaceut Inc, Boston, MA USA

[7] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA

来源：

CLINICAL IMAGING | 2017年 / 45卷

关键词：

Hyperpolarized helium MRI; Cystic fibrosis; Magnetic resonance imaging; Child; Infant; AIR-FLOW OBSTRUCTION; CYSTIC-FIBROSIS; MRI; ASTHMA; SPIROMETRY; DISEASE; RECONSTRUCTION; PERSPECTIVE; GAS; CT;

D O I：

10.1016/j.clinimag.2017.04.004

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose: To develop and evaluate a protocol for hyperpolarized helium-3 (HHe) ventilation magnetic resonance imaging (MRI) of the lungs of non-sedated infants and children. Materials and methods: HHe ventilation MRI was performed on seven children <= 4years old. Contiguous 2D-spiral helium-3 images were acquired sequentially with a scan time of <= 0.2 s/slice. Results: Motion-artifact-free, high signal-to-noise ratio (SNR) images of lung ventilation were obtained. Gas was homogeneously distributed in healthy individuals; focal ventilation defects were found in patients with respiratory diseases. Conclusion: HHe ventilation MRI can aid assessment of pediatric lung disease even at a young age. (C) 2017 The Authors. Published by Elsevier Inc.

引用

页码：105 / 110

页数：6

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