Canagliflozin reduces epicardial fat in patients with type 2 diabetes mellitus

被引：131

作者：

Yagi, Shusuke ^{[1
,2
,3
]}

Hirata, Yukina ^{[4
]}

Ise, Takayuki ^{[1
]}

Kusunose, Kenya ^{[1
]}

Yamada, Hirotsugu ^{[1
]}

Fukuda, Daiju ^{[1
,5
]}

Salim, Hotimah Masdan ^{[1
]}

Maimaituxun, Gulinu ^{[1
]}

Nishio, Susumu ^{[4
]}

Takagawa, Yuriko ^{[1
]}

Hama, Saori ^{[1
]}

Matsuura, Tomomi ^{[1
]}

Yamaguchi, Koji ^{[1
]}

Tobiume, Takeshi ^{[1
]}

Soeki, Takeshi ^{[1
]}

Wakatsuki, Tetsuzo ^{[1
]}

Aihara, Ken-ichi ^{[6
]}

Akaike, Masashi ^{[7
]}

Shimabukuro, Michio ^{[5
,8
]}

Sata, Masataka ^{[1
]}

机构：

[1] Tokushima Univ, Grad Sch Biomed Sci, Dept Cardiovasc Med, 3-18-15,Kuramoto Cho, Tokushima 7708503, Japan

[2] Tokushima Univ, Dept Community Med & Human Resource Dev, Grad Sch Biomed Sci, Tokushima, Japan

[3] Shikoku Cent Hosp, Dept Internal Med, Shikokuchuo, Ehime, Japan

[4] Tokushima Univ Hosp, Ultrasound Examinat Ctr, Tokushima, Japan

[5] Tokushima Univ, Dept Cardiodiabet Med, Grad Sch Biomed Sci, Tokushima, Japan

[6] Tokushima Univ, Dept Community Med Diabet & Metab Disorders, Grad Sch Biomed Sci, Tokushima, Japan

[7] Tokushima Univ, Dept Med Educ, Grad Sch Biomed Sci, Tokushima, Japan

[8] Fukushima Med Univ, Dept Diabet Endocrinol & Metab, Sch Med, Fukushima, Japan

来源：

DIABETOLOGY & METABOLIC SYNDROME | 2017年 / 9卷

关键词：

Epicardial adipose tissue; SGLT2; inhibitors; Echocardiography; ADIPOSE-TISSUE THICKNESS; CORONARY-ARTERY-DISEASE; VISCERAL ABDOMINAL FAT; SERUM URIC-ACID; INSULIN-RESISTANCE; PERICARDIAL FAT; WEIGHT-LOSS; CALCIFICATION; ACCUMULATION; METAANALYSIS;

D O I：

10.1186/s13098-017-0275-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: It is unknown whether canagliflozin, a selective sodium glucose co-transporter 2 inhibitor, reduces epicardial adipose tissue (EAT) thickness, which is associated with insulin resistance and is a risk factor for coronary artery disease. Methods and results: We administered 100 mg of canagliflozin for 6 months to 13 patients with type 2 diabetes mellitus. We evaluated glycemic control, visceral adipose tissue (VAT) area and subcutaneous adipose tissue (SAT) area, and skeletal muscle mass by using impedance methods, and EAT thickness by using echocardiography. Canagliflozin treatment for 6 months decreased hemoglobin A1c level from 7.1 +/- 0.5% to 6.7 +/- 0.6% (P < 0.05) and decreased EAT thickness from 9.3 +/- 2.5 to 7.3 +/- 2.0 mm (P < 0.001), along with a trend of decreasing VAT and SAT area. No association was found between any of these changes. Conclusion: Canagliflozin reduced EAT thickness in patients with type 2 diabetes mellitus independent of its effect on lowering blood glucose, suggesting that canagliflozin may have an effect in preventing cardiovascular events in these patients (UMIN000021327).

引用

页数：7

共 32 条

[1] Perivascular adipose tissue as a regulator of vascular disease pathogenesis: identifying novel therapeutic targets [J].

Akoumianakis, Ioannis ;

Tarun, Akansha ;

Antoniades, Charalambos .

BRITISH JOURNAL OF PHARMACOLOGY, 2017, 174 (20) :3411-3424

[2] Luseogliflozin reduces epicardial fat accumulation in patients with type 2 diabetes: a pilot study [J].

Bouchi, Ryotaro ;

Terashima, Masahiro ;

Sasahara, Yuriko ;

Asakawa, Masahiro ;

Fukuda, Tatsuya ;

Takeuchi, Takato ;

Nakano, Yujiro ;

Murakami, Masanori ;

Minami, Isao ;

Izumiyama, Hajime ;

Hashimoto, Koshi ;

Yoshimoto, Takanobu ;

Ogawa, Yoshihiro .

CARDIOVASCULAR DIABETOLOGY, 2017, 16

[3] Adverse drug events observed in patients with type 2 diabetes mellitus treated with 100 mg versus 300 mg canagliflozin: a systematic review and meta-analysis of published randomized controlled trials [J].

Bundhun, Pravesh Kumar ;

Janoo, Girish ;

Huang, Feng .

BMC PHARMACOLOGY & TOXICOLOGY, 2017, 18

[4] Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial [J].

Cefalu, William T. ;

Leiter, Lawrence A. ;

Yoon, Kun-Ho ;

Arias, Pablo ;

Niskanen, Leo ;

Xie, John ;

Balis, Dainius A. ;

Canovatchel, William ;

Meininger, Gary .

LANCET, 2013, 382 (9896) :941-950

[5] SGLT2 inhibitor lowers serum uric acid through alteration of uric acid transport activity in renal tubule by increased glycosuria [J].

Chino, Yukihiro ;

Samukawa, Yoshishige ;

Sakai, Soichi ;

Nakai, Yasuhiro ;

Yamaguchi, Jun-ichi ;

Nakanishi, Takeo ;

Tamai, Ikumi .

BIOPHARMACEUTICS & DRUG DISPOSITION, 2014, 35 (07) :391-404

[6] Gender disparities in the association between epicardial adipose tissue volume and coronary atherosclerosis: A 3-dimensional cardiac computed tomography imaging study in Japanese subjects [J].

Dagvasumberel, Munkhbaatar ;

Shimabukuro, Michio ;

Nishiuchi, Takeshi ;

Ueno, Junji ;

Takao, Shoichiro ;

Fukuda, Daiju ;

Hirata, Yoichiro ;

Kurobe, Hirotsugu ;

Soeki, Takeshi ;

Iwase, Takashi ;

Kusunose, Kenya ;

Niki, Toshiyuki ;

Yamaguchi, Koji ;

Taketani, Yoshio ;

Yagi, Shusuke ;

Tomita, Noriko ;

Yamada, Hirotsugu ;

Wakatsuki, Tetsuzo ;

Harada, Masafumi ;

Kitagawa, Tetsuya ;

Sata, Masataka .

CARDIOVASCULAR DIABETOLOGY, 2012, 11

[7] Effect of canagliflozin on serum uric acid in patients with type 2 diabetes mellitus [J].

Davies, M. J. ;

Trujillo, A. ;

Vijapurkar, U. ;

Damaraju, C. V. ;

Meininger, G. .

DIABETES OBESITY & METABOLISM, 2015, 17 (04) :426-429

[8] Ipragliflozin Reduces Epicardial Fat Accumulation in Non-Obese Type 2 Diabetic Patients with Visceral Obesity: A Pilot Study [J].

Fukuda, Tatsuya ;

Bouchi, Ryotaro ;

Terashima, Masahiro ;

Sasahara, Yuriko ;

Asakawa, Masahiro ;

Takeuchi, Takato ;

Nakano, Yujiro ;

Murakami, Masanori ;

Minami, Isao ;

Izumiyama, Hajime ;

Hashimoto, Koshi ;

Yoshimoto, Takanobu ;

Ogawa, Yoshihiro .

DIABETES THERAPY, 2017, 8 (04) :851-861

[9] Clinical Utility of Measuring Epicardial Adipose Tissue Thickness with Echocardiography Using a High-Frequency Linear Probe in Patients with Coronary Artery Disease [J].

Hirata, Yukina ;

Yamada, Hirotsugu ;

Kusunose, Kenya ;

Iwase, Takashi ;

Nishio, Susumu ;

Hayashi, Shuji ;

Bando, Mika ;

Amano, Rie ;

Yamaguchi, Koji ;

Soeki, Takeshi ;

Wakatsuki, Tetsuzo ;

Sata, Masataka .

JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 2015, 28 (10) :1240-+

[10] Epicardial adipose tissue and insulin resistance in obese subjects [J].

Iacobellis, G ;

Leonetti, F .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (11) :6300-6302

← 1 2 3 4 →