Negative Anti-C1q Antibody Titers May Influence Therapeutic Decisions and Reduce the Number of Renal Biopsies in Systemic Lupus Erythematosus

被引：8

作者：

Guerreiro de Moura, Carlos Geraldo ^{[1
,2
,3
]}

Pitangueira Mangueira, Cristovao Luis ^{[5
,6
]}

Sampaio Cruz, Luzia Arlinda ^{[4
]}

Sampaio Cruz, Constanca Margarida ^{[2
]}

机构：

[1] Hosp Santo Antonio, Bahiana Sch Med & Publ Hlth, Salvador, BA, Brazil

[2] Hosp Santo Antonio, Coordinat Residency Program Internal Med, Salvador, BA, Brazil

[3] Hosp Santo Antonio, Clin Rheumatol, Salvador, BA, Brazil

[4] Bahiana Sch Med & Publ Hlth, Clin Kidney & Hypertens, Salvador, BA, Brazil

[5] Univ Sao Paulo, Hosp Fac Med, Sect Auto Antibodies Cent Lab LIM 03, BR-05508 Sao Paulo, Brazil

[6] Hosp Israelita Albert Einstein, Israel Inst Educ & Res Sao Paulo, Dept Pathol, Sao Paulo, Brazil

来源：

NEPHRON CLINICAL PRACTICE | 2011年 / 118卷 / 04期

关键词：

Systemic Lupus Erythematosus Disease Activity Index; Anti-C1q; Systemic lupus erythematosus; Lupus nephritis; COLLAGEN-LIKE REGION; IGG AUTOANTIBODIES; PREDICTIVE-VALUE; APOPTOTIC CELLS; C1Q; NEPHRITIS; GLOMERULI; DEPOSIT;

D O I：

10.1159/000323388

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

In a cross-sectional study involving 62 patients with systemic lupus erythematosus (SLE), we found that patients with biopsy-proven lupus nephritis (LN) had higher titers of anti-C1q antibodies than active SLE without nephritis patients. Anti-C1q was associated with a negative predictive value of 94.59%, a positive predictive value of 52%, a sensitivity of 86.66% and a specificity of 74.47% for the diagnosis of LN. We conclude that high titers of anti-C1q antibodies are strongly associated with the presence of active LN, and the negative predictive value of this test for diagnosing LN is very high; therefore, it can influence therapeutic decisions and reduce the number of renal biopsies in patients with SLE. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：C355 / C360

页数：6

共 17 条

[1] Autoantibodies against Complement C1q Specifically Target C1q Bound on Early Apoptotic Cells [J].

Bigler, Cornelia ;

Schaller, Monica ;

Perahud, Iryna ;

Osthoff, Michael ;

Trendelenburg, Marten .

JOURNAL OF IMMUNOLOGY, 2009, 183 (05) :3512-3521

[2] CHANGES IN ANTIBODIES TO C1Q PREDICT RENAL RELAPSES IN SYSTEMIC LUPUS-ERYTHEMATOSUS [J].

COREMANS, IEM ;

SPRONK, PE ;

BOOTSMA, H ;

DAHA, MR ;

VANDERVOORT, EAM ;

KATER, L ;

BREEDVELD, FC ;

KALLENBERG, CGM .

AMERICAN JOURNAL OF KIDNEY DISEASES, 1995, 26 (04) :595-601

[3]

Gunnarsson I, 1997, BRIT J RHEUMATOL, V36, P32

[4]

Gunnarsson I, 2002, J RHEUMATOL, V29, P693

[5] Antibodies to C1q in systemic lupus erythematosus: Characteristics and relation to Fc gamma RIIA alleles [J].

Haseley, LA ;

Wisnieski, JJ ;

Denburg, MR ;

MichaelGrossman, AR ;

Ginzler, EM ;

Gourley, MF ;

Hoffman, JH ;

Kimberly, RP ;

Salmon, JE .

KIDNEY INTERNATIONAL, 1997, 52 (05) :1375-1380

[6] Autoimmunity to protective molecules:: is it the perpetuum mobile (vicious cycle) of autoimmune rheumatic diseases? [J].

Kravitz, Martine Szyper ;

Shoenfeld, Yehuda .

NATURE CLINICAL PRACTICE RHEUMATOLOGY, 2006, 2 (09) :481-490

[7] Deposition of antibodies to the collagen-like region of C1q in renal glomeruli of patients with proliferative lupus glomerulonephritis [J].

Mannik, M ;

Wener, MH .

ARTHRITIS AND RHEUMATISM, 1997, 40 (08) :1504-1511

[8] Anti-C1q antibodies in nephritis: correlation between titres and renal disease activity and positive predictive value in systemic lupus erythematosus [J].

Marto, N ;

Bertolaccini, ML ;

Calabuig, E ;

Hughes, GRV ;

Khamashta, MA .

ANNALS OF THE RHEUMATIC DISEASES, 2005, 64 (03) :444-448

[9] C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells [J].

Ogden, CA ;

deCathehneau, A ;

Hoffmann, PR ;

Bratton, D ;

Ghebrehiwet, B ;

Fadok, VA ;

Henson, PM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (06) :781-795

[10] Are anti-C1q antibodies different from other SLE autoantibodies? [J].

Pickering, Matthew C. ;

Botto, Marina .

NATURE REVIEWS RHEUMATOLOGY, 2010, 6 (08) :490-493

← 1 2 →