One-pot three component synthesis of 3,5-disubstituted 2,6-dicyanoaniline derivatives using 4-dimethylaminopyridine (DMAP) as a catalyst

被引：16

作者：

Bhattacharjee, Suchandra ^{[1
]}

Khan, Abu T. ^{[1
,2
]}

机构：

[1] Indian Inst Technol, Dept Chem, Gauhati 781039, India

[2] Aliah Univ, IIA-27, Kolkata 700156, W Bengal, India

来源：

TETRAHEDRON LETTERS | 2016年 / 57卷 / 27-28期

关键词：

One-pot synthesis; beta-Nitro-olefin; Aldehydes; Malononitrile; DMAP; 3,5-Disubstituted 2,6-dicyanoaniline; CONSTRUCTION; MOLECULES; EFFICIENT; DESIGN; WATER;

D O I：

10.1016/j.tetlet.2016.05.097

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthetic protocol was devised for the synthesis of 3,5-disubstituted 2,6-dicyanoaniline from malononitrile, aldehydes, and beta-nitro-olefins by using N,N-dimethyl-4-aminopyridine (DMAP) as a nudeophilic catalyst. The important aspects of the present methodology are: use of non-toxic organo-catalyst, shorter reaction time, compatibility with wide range of substrates, and good yields. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：2994 / 2997

页数：4

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