Atheroprotective potentials of curcuminoids against ginger extract in hypercholesterolaemic rabbits

被引：16

作者：

Elseweidy, M. M. ^{[1
]}

Younis, N. N. ^{[1
]}

Elswefy, S. E. ^{[1
]}

Abdallah, F. R. ^{[1
]}

El-Dahmy, S. I. ^{[2
]}

Elnagar, G. ^{[1
]}

Kassem, H. M. ^{[1
]}

机构：

[1] Zagazig Univ, Dept Biochem, Fac Pharm, Zagazig 44519, Egypt

[2] Zagazig Univ, Dept Pharmacognosy, Fac Pharm, Zagazig 44519, Egypt

来源：

NATURAL PRODUCT RESEARCH | 2015年 / 29卷 / 10期

关键词：

ox-LDL; curcuminoids; cardiovascular risk; HDL-C; hypercholesterolaemia; CETP; ginger; C-REACTIVE PROTEIN; APOLIPOPROTEIN-A-I; DENSITY-LIPOPROTEIN; ZINGIBER-OFFICINALE; HDL-CHOLESTEROL; ATHEROSCLEROSIS; LDL; MATRIX-METALLOPROTEINASE-9; INFLAMMATION; OXIDATION;

D O I：

10.1080/14786419.2014.957699

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The anti-atherogenic potentials of total ginger (Zingiber officinale) extract (TGE) or curcuminoids extracted from turmeric (Curcuma longa), members of family Zingiberaceae, were compared in hypercholesterolaemia. Rabbits were fed either normal or atherogenic diet. The rabbits on atherogenic diet received treatments with TGE or curcumenoids and placebo concurrently for 6 weeks (n=6). The anti-atherogenic effects of curcuminoids and ginger are mediated via multiple mechanisms. This effect was correlated with their ability to lower cholesteryl ester transfer protein activity. Ginger extract exerted preferential effects on plasma lipids, reverse cholesterol transport, cholesterol synthesis and inflammatory status. Curcuminoids, however, showed superior antioxidant activity.

引用

页码：961 / 965

页数：5

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