Roles of transforming growth factor-α in mammary development and disease

被引：24
作者：
Booth, Brian W. [1 ]
Smith, Gilbert H. [1 ]
机构：
[1] NCI, NIH, Mammary Biol & Tumorigenesis Lab, Bethesda, MD 20892 USA
来源：
GROWTH FACTORS | 2007年 / 25卷 / 04期
关键词：
TGF alpha; mammary; development; cancer;
D O I：
10.1080/08977190701750698
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Transforming growth factor-alpha (TGF alpha) is a member of the epidermal growth factor (EGF) family. Expression of TGFa is highly regulated in response to exogenous cellular signals including cytokines and other growth factors. The growth factor has been found to be indispensable for proper development of many tissues and organs. TGFa has also been implicated in numerous disease states including forms of breast cancer. This minireview summarizes the basic biology of TGFa and its actions during normal and pathogenic development of the mammary epithelium.
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收藏
页码：227 / 235
页数：9
相关论文
共 97 条
  • [1] Cyclooxygenase-2 transactivates the epidermal growth factor receptor through specific E-prostanoid receptors and Tumor Necrosis Factor-α converting enzyme
    Al-Salihi, Mazin A.
    Ulmer, Scott C.
    Doan, Thao
    Nelson, Cory D.
    Crotty, Tracy
    Prescott, Stephen M.
    Stafforini, Diana M.
    Topham, Matthew K.
    [J]. CELLULAR SIGNALLING, 2007, 19 (09) : 1956 - 1963
  • [2] Prolactin potentiates transforming growth factor α induction of mammary neoplasia in transgenic mice
    Arendt, LM
    Rose-Hellekant, TA
    Sandgren, EP
    Schuler, LA
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2006, 168 (04) : 1365 - 1374
  • [3] PRODUCTION OF TRANSFORMING GROWTH FACTOR-ALPHA BY NORMAL RAT SMALL-INTESTINE
    BARNARD, JA
    POLK, WH
    MOSES, HL
    COFFEY, RJ
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 261 (06): : C994 - C1000
  • [4] Berkowitz EA, 1996, CELL GROWTH DIFFER, V7, P1271
  • [5] BLASBAND AJ, 1990, ONCOGENE, V5, P1213
  • [6] TGFβ1 and TGFα contrarily affect alveolar survival and tumorigenesis in mouse mammary epithelium
    Booth, Brian W.
    Jhappan, Chamelli
    Merlino, Glenn
    Smith, Gilbert H.
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2007, 120 (03) : 493 - 499
  • [7] IL-13-induced proliferation of airway epithelial cells: mediation by intracellular growth factor mobilization and ADAM17
    Booth, Brian W.
    Sandifer, Tracy
    Martin, Erika L.
    Martin, Linda D.
    [J]. RESPIRATORY RESEARCH, 2007, 8 (1):
  • [8] Interleukin-13 induces proliferation of human airway epithelial cells in vitro via a mechanism mediated by transforming growth factor-α
    Booth, BW
    Adler, KB
    Bonner, JC
    Tournier, F
    Martin, LD
    [J]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2001, 25 (06) : 739 - 743
  • [9] The carboxyl-terminal valine residues of ProTGF alpha are required for its efficient maturation and intracellular routing
    Briley, GP
    Hissong, MA
    Chiu, ML
    Lee, DC
    [J]. MOLECULAR BIOLOGY OF THE CELL, 1997, 8 (08) : 1619 - 1631
  • [10] Human eosinophils induce mucin production in airway epithelial cells via epidermal growth factor receptor activation
    Burgel, PR
    Lazarus, SC
    Tam, DCW
    Ueki, IF
    Atabai, K
    Birch, M
    Nadel, JA
    [J]. JOURNAL OF IMMUNOLOGY, 2001, 167 (10) : 5948 - 5954
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