First Synthesis of a Representative, Natural Pterin Glycoside: 2′-O-(α-D-Glucopyranosyl) biopterin

被引：0

作者：

Hanaya, Tadashi ^{[1
]}

Yamamoto, Hiroshi ^{[2
]}

Pfleiderer, Wolfgang ^{[3
]}

机构：

[1] Okayama Univ, Fac Sci, Dept Chem, Okayama 7008530, Japan

[2] Shujitsu Univ, Sch Pharm, Okayama 7038516, Japan

[3] Univ Konstanz, Fachbereich Chem, D-78457 Constance, Germany

来源：

PTERIDINES | 2009年 / 20卷

关键词：

biopterin D-glucoside; pterin glycoside; glycosylation; protecting groups; SYNECHOCOCCUS SP PCC-7942; EFFICIENT SYNTHESIS; TEPIDOPTERIN; PTERIDINES; LIMIPTERIN; GLUCOSIDE;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glycosylation of N(2)-(N, N-dimethylaminomethylene)-1'-O-(4-methoxybenzyl)-3-[2-(4-nitrophenyl) ethyl] biopterin (14) with the novel donor 4,6-di-O-acetyl-2,3-di-O-(4-methoxy-benzyl)-alpha-D- -glucopyranosyl bromide (19) in the presence of silver triflate and tetramethylurea predominantly afforded the corresponding a-D-glucopyranoside (20a), from which 2'-O-(alpha-D-glucopyranosyl) biopterin (1) was obtained by the successive removal of the protecting groups.

引用

页码：36 / 41

页数：6

共 23 条

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