Trust your gut: an early life lesson for T cells

被引：1

作者：

Cowan, Jennifer E. ^{[1
]}

机构：

[1] NCI, T Cell Biol & Dev Unit, Lab Genome Integr, Ctr Canc Res, Bethesda, MD 20892 USA

来源：

TRENDS IN IMMUNOLOGY | 2021年 / 42卷 / 10期

关键词：

INDUCE;

D O I：

10.1016/j.it.2021.08.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Zegarra-Ruiz et al. demonstrate that gut microbe-specific T cells are selected within the thymus exclusively during early life in mice. This selection is dependent on CX3CR1(+) dendritic cells migrating from the gut carrying bacterially derived antigens into the thymus. This offers new insight into how gut microbiota influence T cell development.

引用

页码：844 / 845

页数：2

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