Conventional and microwave assisted synthesis of 2-oxo-4-substituted aryl-azetidine derivatives of benzotriazole: A new class of biological compounds

被引：58

作者：

Dubey, Adesh ^{[1
]}

Srivastava, S. K. ^{[1
]}

Srivastava, S. D. ^{[1
]}

机构：

[1] Dr Hari Singh Gour Cent Univ, Synthet Organ Chem Lab, Dept Chem, Sagar 470003, MP, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 01期

关键词：

Antimicrobial; Antitubercular; Azetidinone; Conventional and microwave irradiation; PHARMACOLOGICAL EVALUATION; EFFICIENT SYNTHESIS; 2-AZETIDINONES;

D O I：

10.1016/j.bmcl.2010.10.057

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We report herein the synthesis and biological activity of a new kind of azetidinone derivatives of benzotriazole. The reaction was carried out by both conventional and microwave methods. The chemical structures of all the synthesized compounds were deduced according to FTIR, H-1 NMR, C-13 NMR and FAB-mass spectral along with microanalytical data. All the synthesized compounds of series 5a-i were evaluated for their antitubercular activity against Mycobacterium tuberculosis H37RV and antimicrobial activity against some selected microorganism. Unexpectedly, some azetidinone derivatives of benzotriazole displayed better activities. (C) 2010 Published by Elsevier Ltd.

引用

页码：569 / 573

页数：5

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