Potential Role of Olive Oil Phenolic Compounds in the Prevention of Neurodegenerative Diseases

被引：165

作者：

Rodriguez-Morato, Jose ^{[1
,2
,3
]}

Xicota, Laura ^{[1
,2
,4
]}

Fito, Montse ^{[3
,5
]}

Farre, Magi ^{[1
,6
]}

Dierssen, Mara ^{[4
,7
]}

de la Torre, Rafael ^{[1
,2
,3
]}

机构：

[1] IMIM Inst Hosp Mar Invest Mediques, Neurosci Res Program, Human Pharmacol & Clin Neurosci Res Grp, Barcelona 08003, Spain

[2] Univ Pompeu Fabra CEXS UPF, Dept Expt & Hlth Sci, Barcelona 08003, Spain

[3] CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Santiago De Compostela 15706, Spain

[4] Ctr Genom Regulat, Cellular & Syst Neurobiol Res Grp, Barcelona 08003, Spain

[5] IMIM Inst Hosp Mar Invest Mediques, Cardiovasc Risk & Nutr Res Grp, Program Epidemiol, Barcelona 08003, Spain

[6] Univ Autonoma Barcelona, Dept Pharmacol Therapeut & Toxicol, E-08193 Barcelona, Spain

[7] CIBERER, Barcelona 08003, Spain

来源：

MOLECULES | 2015年 / 20卷 / 03期

关键词：

ADDRESSING ANALYTICAL REQUIREMENTS; VASCULAR ENDOTHELIAL-CELLS; PIGMENT EPITHELIAL-CELLS; SUPPORT HEALTH CLAIMS; MEDITERRANEAN DIET; OXIDATIVE STRESS; IN-VIVO; NRF2; ACTIVATION; GENE-EXPRESSION; HYDROXYTYROSOL PROTECTS;

D O I：

10.3390/molecules20034655

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adherence to the Mediterranean Diet (MD) has been associated with a reduced incidence of neurodegenerative diseases and better cognitive performance. Virgin olive oil, the main source of lipids in the MD, is rich in minor phenolic components, particularly hydroxytyrosol (HT). HT potent antioxidant and anti-inflammatory actions have attracted researchers' attention and may contribute to neuroprotective effects credited to MD. In this review HT bioavailability and pharmacokinetics are presented prior to discussing health beneficial effects. In vitro and in vivo neuroprotective effects together with its multiple mechanisms of action are reviewed. Other microconstituents of olive oil are also considered due to their potential neuroprotective effects (oleocanthal, triterpenic acids). Finally, we discuss the potential role of HT as a therapeutic tool in the prevention of neurodegenerative diseases.

引用

页码：4655 / 4680

页数：26

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