The Hidden Role of Hydrogen Sulfide Metabolism in Cancer

被引：57
作者：
Wang, Rong-Hsuan [1 ]
Chu, Yu-Hsin [1 ,2 ]
Lin, Kai-Ti [1 ,3 ]
机构：
[1] Natl Tsing Hua Univ, Coll Life Sci, Inst Biotechnol, Hsinchu 300, Taiwan
[2] Natl Tsing Hua Univ, Coll Life Sci, Dept Life Sci, Hsinchu 300, Taiwan
[3] Natl Tsing Hua Univ, Coll Life Sci, Dept Med Sci, Hsinchu 300, Taiwan
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 12期
关键词：
hydrogen sulfide; gasotransmitter; persulfidation; cystathionine beta-synthase; cystathionine gamma-lyase; 3-mercaptopyruvate sulfurtransferase; cancer metabolism; CYSTATHIONINE-BETA-SYNTHASE; NF-KAPPA-B; EPITHELIAL-MESENCHYMAL TRANSITION; ISCHEMIA-REPERFUSION INJURY; H2S-INDUCED S-SULFHYDRATION; GAMMA-LYASE; 3-MERCAPTOPYRUVATE SULFURTRANSFERASE; SELECTIVE INHIBITORS; DNA-REPAIR; IRREVERSIBLE INACTIVATION;
D O I：
10.3390/ijms22126562
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hydrogen Sulfide (H2S), an endogenously produced gasotransmitter, is involved in various important physiological and disease conditions, including vasodilation, stimulation of cellular bioenergetics, anti-inflammation, and pro-angiogenesis. In cancer, aberrant up-regulation of H2S-producing enzymes is frequently observed in different cancer types. The recognition that tumor-derived H2S plays various roles during cancer development reveals opportunities to target H2S-mediated signaling pathways in cancer therapy. In this review, we will focus on the mechanism of H2S-mediated protein persulfidation and the detailed information about the dysregulation of H2S-producing enzymes and metabolism in different cancer types. We will also provide an update on mechanisms of H2S-mediated cancer progression and summarize current options to modulate H2S production for cancer therapy.
引用
收藏
页数：16
相关论文
共 172 条
[1]  
Abe K, 1996, J NEUROSCI, V16, P1066
[2]   Human Polycomb 2 Protein Is a SUMO E3 Ligase and Alleviates Substrate-Induced Inhibition of Cystathionine β-Synthase Sumoylation [J].
Agrawal, Nitish ;
Banerjee, Ruma .
PLOS ONE, 2008, 3 (12)
[3]   Hydrogen Sulfide Signaling in Plants: Emerging Roles of Protein Persulfidation [J].
Aroca, Angeles ;
Gotor, Cecilia ;
Romero, Luis C. .
FRONTIERS IN PLANT SCIENCE, 2018, 9
[4]   S-Sulfhydration: A Cysteine Posttranslational Modification in Plant Systems [J].
Aroca, Angeles ;
Serna, Antonio ;
Gotor, Cecilia ;
Romero, Luis C. .
PLANT PHYSIOLOGY, 2015, 168 (01) :334-U586
[5]   Pharmacological induction of mesenchymal-epithelial transition via inhibition of H2S biosynthesis and consequent suppression of ACLY activity in colon cancer cells [J].
Ascencao, Kelly ;
Dilek, Nahzli ;
Augsburger, Fiona ;
Panagaki, Theodora ;
Zuhra, Karim ;
Szabo, Csaba .
PHARMACOLOGICAL RESEARCH, 2021, 165
[6]   Selectivity of commonly used pharmacological inhibitors for cystathionine synthase (CBS) and cystathionine lyase (CSE) [J].
Asimakopoulou, Antonia ;
Panopoulos, Panagiotis ;
Chasapis, Christos T. ;
Coletta, Ciro ;
Zhou, Zongmin ;
Cirino, Giuseppe ;
Giannis, Athanassios ;
Szabo, Csaba ;
Spyroulias, Georgios A. ;
Papapetropoulos, Andreas .
BRITISH JOURNAL OF PHARMACOLOGY, 2013, 169 (04) :922-932
[7]   Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation, Migration, and Bioenergetics in Murine Colon Cancer Cells [J].
Augsburger, Fiona ;
Randi, Elisa B. ;
Jendly, Mathieu ;
Ascencao, Kelly ;
Dilek, Nahzli ;
Szabo, Csaba .
BIOMOLECULES, 2020, 10 (03)
[8]   Novel Aryl-Substituted Pyrimidones as Inhibitors of 3-Mercaptopyruvate Sulfurtransferase with Antiproliferative Efficacy in Colon Cancer [J].
Bantzi, Marina ;
Augsburger, Fiona ;
Loup, Jeremie ;
Berset, Yan ;
Vasilakaki, Sofia ;
Myrianthopoulos, Vassilios ;
Mikros, Emmanuel ;
Szabo, Csaba ;
Bochet, Christian G. .
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 64 (09) :6221-6240
[9]   2-Arylidene Hydrazinecarbodithioates as Potent, Selective Inhibitors of Cystathionine γ-Lyase (CSE) [J].
Bhattacharjee, Abir ;
Sinha, Antara ;
Ratia, Kiira ;
Yin, Liang ;
Delgado-Rivera, Loruhama ;
Petukhov, Pavel A. ;
Thatcher, Gregory R. J. ;
Wardrop, Duncan J. .
ACS MEDICINAL CHEMISTRY LETTERS, 2017, 8 (12) :1241-1245
[10]   Cystathionine Beta-Synthase (CBS) Contributes to Advanced Ovarian Cancer Progression and Drug Resistance [J].
Bhattacharyya, Sanjib ;
Saha, Sounik ;
Giri, Karuna ;
Lanza, Ian R. ;
Nair, K. Sreekumar ;
Jennings, Nicholas B. ;
Rodriguez-Aguayo, Cristian ;
Lopez-Berestein, Gabriel ;
Basal, Eati ;
Weaver, Amy L. ;
Visscher, Daniel W. ;
Cliby, William ;
Sood, Anil K. ;
Bhattacharya, Resham ;
Mukherjee, Priyabrata .
PLOS ONE, 2013, 8 (11)
12345678910