TRIM-ing down tolls

被引：10

作者：

Bowie, Andrew G. ^{[1
]}

机构：

[1] Trinity Coll Dublin, Sch Biochem & Immunol, Dublin 2, Ireland

来源：

NATURE IMMUNOLOGY | 2008年 / 9卷 / 04期

关键词：

D O I：

10.1038/ni0408-348

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Activation of the transcription factor NF-kappa B by Toll-like receptors must be controlled to avoid excessive inflammation. The tripartite-motif protein family member. TRIM30 alpha has now been shown to mediate a negative regulatory feedback mechanism curtailing such responses.

引用

页码：348 / 350

页数：3

共 13 条

[1] TAK1-dependent signaling requires functional interaction with TAB2/TAB3
Besse, Arnaud
Lamothe, Betty
Campos, Alejandro D.
Webster, William K.
Maddineni, Upendra
Lin, Su-Chang
Wu, Hao
Darnay, Bryant G.
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (06) : 3918 - 3928
[2] Ubiquitin signalling in the NF-κB pathway
Chen, ZJJ
[J]. NATURE CELL BIOLOGY, 2005, 7 (08) : 758 - U19
[3] Forward genetic analysis of Toll-like receptor responses in wild-derived mice reveals a novel antiinflammatory role for IRAK1BP1
Conner, James R.
Smirnova, Irina I.
Poltorak, Alexander
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (02) : 305 - 314
[4] Induction of in vitro reprogramming by toll-like receptor (TLR)2 and TLR4 agonists in murine macrophages:: Effects of TLR "homotolerance" versus "heterotolerance" on NF-κB signaling pathway components
Dobrovolskaia, MA
Medvedev, AE
Thomas, KE
Cuesta, N
Toshchakov, V
Ren, TB
Cody, MJ
Michalek, SM
Rice, NR
Vogel, SN
[J]. JOURNAL OF IMMUNOLOGY, 2003, 170 (01) : 508 - 519
[5] Gene-specific control of inflammation by TLR-induced chromatin modifications
Foster, Simmie L.
Hargreaves, Diana C.
Medzhitov, Ruslan
[J]. NATURE, 2007, 447 (7147) : 972 - U4
[6] TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity
Gack, Michaela U.
Shin, Young C.
Joo, Chul-Hyun
Urano, Tomohiko
Liang, Chengyu
Sun, Lijun
Takeuchi, Osamu
Akira, Shizuo
Chen, Zhijian
Inoue, Satoshi
Jung, Jae U.
[J]. NATURE, 2007, 446 (7138) : 916 - U2
[7] Shared principles in NF-κB signaling
Hayden, Matthew S.
Ghosh, Sankar
[J]. CELL, 2008, 132 (03) : 344 - 362
[8] Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2
Hong, Suntaek
Lim, Seunghwan
Li, Allen G.
Lee, Chan
Lee, Youn Sook
Lee, Eun-Kyung
Park, Seok Hee
Wang, Xiao-Jing
Kim, Seong-Jin
[J]. NATURE IMMUNOLOGY, 2007, 8 (05) : 504 - 513
[9] The age of crosstalk: Phosphorylation, ubiquitination, and beyond
Hunter, Tony
[J]. MOLECULAR CELL, 2007, 28 (05) : 730 - 738
[10] Trim family proteins:: Retroviral restriction and antiviral defence
Nisole, S
Stoye, JP
Saïb, A
[J]. NATURE REVIEWS MICROBIOLOGY, 2005, 3 (10) : 799 - 808

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