TRIM-ing down tolls

被引：10

作者：

Bowie, Andrew G. ^{[1
]}

机构：

[1] Trinity Coll Dublin, Sch Biochem & Immunol, Dublin 2, Ireland

来源：

NATURE IMMUNOLOGY | 2008年 / 9卷 / 04期

关键词：

D O I：

10.1038/ni0408-348

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Activation of the transcription factor NF-kappa B by Toll-like receptors must be controlled to avoid excessive inflammation. The tripartite-motif protein family member. TRIM30 alpha has now been shown to mediate a negative regulatory feedback mechanism curtailing such responses.

引用

页码：348 / 350

页数：3

共 13 条

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