Intrapartum Antibiotic Chemoprophylaxis Policies for the Prevention of Group B Streptococcal Disease Worldwide: Systematic Review

被引：150

作者：

Le Doare, Kirsty ^{[1
,2
,3
,4
]}

O'Driscoll, Megan ^{[1
]}

Turner, Kim ^{[5
]}

Seedat, Farah ^{[6
]}

Russell, Neal J. ^{[7
,8
]}

Seale, Anna C. ^{[7
,9
]}

Heath, Paul T. ^{[3
,4
]}

Lawn, Joy E. ^{[7
]}

Baker, Carol J. ^{[10
,11
,12
]}

Bartlett, Linda ^{[13
]}

Cutland, Clare ^{[14
,15
]}

Gravett, Michael G. ^{[16
,17
]}

Ip, Margaret ^{[18
]}

Madhi, Shabir A. ^{[14
,15
,19
]}

Rubens, Craig E. ^{[16
,20
]}

Saha, Samir K. ^{[21
]}

Schrag, Stephanie ^{[22
]}

Sobanjo-ter Meulen, Ajoke ^{[23
]}

Vekemans, Johan ^{[24
]}

Kampmann, Beate ^{[1
,2
]}

机构：

[1] Imperial Coll London, Ctr Int Child Hlth, Norfolk Pl, London W2 1PG, England

[2] MRC Unit, Fajara, Gambia

[3] Univ London, St Georges Hosp, Inst Infect & Immun, Vaccine Inst, London, England

[4] St Georges Univ Hosp NHS Fdn Trust, London, England

[5] Univ Southern Calif, Global Med, Los Angeles, CA USA

[6] Univ Warwick, Med Sch, Gibbet Hill, Coventry, W Midlands, England

[7] London Sch Hyg & Trop Med, Maternal Adolescent Reprod & Child Hlth Ctr, London, England

[8] Kings Coll London, London, England

[9] Haramaya Univ, Coll Hlth & Med Sci, Dire Dawa, Ethiopia

[10] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA

[11] Baylor Coll Med, Dept Mol Virol, Houston, TX 77030 USA

[12] Baylor Coll Med, Dept Microbiol, Houston, TX 77030 USA

[13] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA

[14] Univ Witwatersrand, Med Res Council, Resp & Meningeal Pathogens Res Unit, Fac Hlth Sci, Johannesburg, South Africa

[15] Univ Witwatersrand, Dept Sci & Technology, Fac Hlth Sci, Natl Res Fdn Vaccine Preventable Dis, Johannesburg, South Africa

[16] Global Alliance Prevent Prematur & Stillbirth, Seattle, WA USA

[17] Univ Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USA

[18] Chinese Univ Hong Kong, Dept Microbiol, Fac Med, Hong Kong, Hong Kong, Peoples R China

[19] Nat Inst Communicable Dis, Natl Hlth Lab Serv, Johannesburg, South Africa

[20] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA

[21] Bangladesh Inst Child Hlth, Dhaka, Bangladesh

[22] Nat Ctr Immunizat & Resp Dis, Ctr Dis Control & Prevent, Atlanta, GA USA

[23] Bill & Melinda Gates Fdn, Seattle, WA USA

[24] WHO, Geneva, Switzerland

来源：

CLINICAL INFECTIOUS DISEASES | 2017年 / 65卷

基金：

比尔及梅琳达.盖茨基金会;

关键词：

group B Streptococcus; intrapartum antibiotic chemoprophylaxis; MATERNAL COLONIZATION; PREGNANT-WOMEN; STILLBIRTHS; PROPHYLAXIS; MICROBIOME; INFECTIONS; CHILDREN; RISK; ERA;

D O I：

10.1093/cid/cix654

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. Intrapartum antibiotic chemoprophylaxis (IAP) prevents most early-onset group B streptococcal (GBS) disease. However, there is no description of how IAP is used around the world. This article is the sixth in a series estimating the burden of GBS disease. Here we aimed to review GBS screening policies and IAP implementation worldwide. Methods. We identified data through (1) systematic literature reviews (PubMed/Medline, Embase, Literature in the Health Sciences in Latin America and the Caribbean [LILACS], World Health Organization library database [WHOLIS], and Scopus) and unpublished data from professional societies and (2) an online survey and searches of policies from medical societies and professionals. We included data on whether an IAP policy was in use, and if so whether it was based on microbiological or clinical risk factors and how these were applied, as well as the estimated coverage (percentage of women receiving IAP where indicated). Results. We received policy information from 95 of 195 (49%) countries. Of these, 60 of 95 (63%) had an IAP policy; 35 of 60 (58%) used microbiological screening, 25 of 60 (42%) used clinical risk factors. Two of 15 (13%) low-income, 4 of 16 (25%) lower-middle-income, 14 of 20 (70%) upper-middle-income, and 40 of 44 (91%) high-income countries had any IAP policy. The remaining 35 of 95 (37%) had no national policy (25/33 from low-income and lower-middle-income countries). Coverage varied considerably; for microbiological screening, median coverage was 80% (range, 20%-95%); for clinical risk factor-based screening, coverage was 29% (range, 10%-50%). Although there were differences in the microbiological screening methods employed, the individual clinical risk factors used were similar. Conclusions. There is considerable heterogeneity in IAP screening policies and coverage worldwide. Alternative global strategies, such as maternal vaccination, are needed to enhance the scope of global prevention of GBS disease.

引用

页码：S143 / S151

页数：9

共 33 条

[1]

ACOG committee opinion, 1996, INT J GYNECOL OBSTET, V54, P197, DOI DOI 10.1016/S0020-7292(96)90083-1

[2]

[Anonymous], 2008, PREV NEON GROEP B ST

[3] Consequences of prophylaxis for group B streptococcal infections of the neonate [J].

Baltimore, Robert S. .

SEMINARS IN PERINATOLOGY, 2007, 31 (01) :33-38

[4] Preterm Birth Associated With Group B Streptococcus Maternal Colonization Worldwide: Systematic Review and Meta- analyses [J].

Bianchi-Jassir, Fiorella ;

Seale, Anna C. ;

Kohli-Lynch, Maya ;

Lawn, Joy E. ;

Baker, Carol J. ;

Bartlett, Linda ;

Cutland, Clare ;

Gravett, Michael G. ;

Heath, Paul T. ;

Ip, Margaret ;

Le Doare, Kirsty ;

Madhi, Shabir A. ;

Saha, Samir K. ;

Schrag, Stephanie ;

Sobanjo-ter Meulen, Ajoke ;

Vekemans, Johan ;

Rubens, Craig E. .

CLINICAL INFECTIOUS DISEASES, 2017, 65 :S133-S142

[5] Changing patterns in neonatal Escherichia coli sepsis and ampicillin resistance in the era of intrapartum antibiotic prophylaxis [J].

Bizzarro, Matthew J. ;

Dembry, Louise-Marie ;

Baltimore, Robert S. ;

Gallagher, Patrick G. .

PEDIATRICS, 2008, 121 (04) :689-696

[6] Manipulation of the Intestinal Microbiome in Newborn Infants [J].

Cacho, Nicole ;

Neu, Josef .

ADVANCES IN NUTRITION, 2014, 5 (01) :114-118

[7] Building a Beneficial Microbiome from Birth [J].

Castanys-Munoz, Esther ;

Martin, Maria J. ;

Vazquez, Enrique .

ADVANCES IN NUTRITION, 2016, 7 (02) :323-330

[8]

Centers for Disease Control and Prevention, 2015, ACT BACT COR SURV AB

[9] An overview of the natural history of early onset group B streptococcal disease in the UK [J].

Colbourn, Tim ;

Gilbert, Ruth .

EARLY HUMAN DEVELOPMENT, 2007, 83 (03) :149-156

[10] Maternal Disease With Group B Streptococcus and Serotype Distribution Worldwide: Systematic Review and Meta-analyses [J].

Hall, Jennifer ;

Adams, Nadine Hack ;