Polymeric microneedles based enzymatic electrodes for electrochemical biosensing of glucose and lactic acid

被引：108

作者：

Calio, A. ^{[1
,2
,3
]}

Dardano, P. ^{[1
,2
]}

Di Palma, V. ^{[2
,4
]}

Bevilacqua, M. F. ^{[2
,4
]}

Di Matteo, A. ^{[2
,4
]}

Iuele, H. ^{[2
]}

De Stefano, L. ^{[1
,2
]}

机构：

[1] CNR, Inst Microelect & Microsyst, Via P Castellino 111, I-80131 Naples, Italy

[2] IMAST Scarl, Piazza Bovio 22, I-80133 Naples, Italy

[3] Univ Naples Federico II, Dept Phys Sci, Via Cinthia, I-80126 Naples, Italy

[4] STMicroelectronics, Via Remo De Feo 1, I-80022 Arzano, Italy

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2016年 / 236卷

关键词：

Microneedles; Photolithography; Polymer; Enzymes; Electrochemistrya; ARRAY FABRICATION; DRUG-DELIVERY; FLUID;

D O I：

10.1016/j.snb.2016.05.156

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Polymeric microneedles (MNs) based working electrodes are fabricated by standard photolithography of poly(ethylene glycol) diacrylate (PEGDA) doped by enzyme, redox mediator and photoinitiator. This flexible device acts as working electrode in electrochemical detection of glucose and lactic acid in solution when glucose oxidase (GOx) and lactose oxidase (LOx) enzymes, respectively, are used. Biosensor showed a linear response in the ranges from 0 to 4 mM and from 0 to 1 mM, for glucose and lactic acid, respectively. A limit of detection equal to 1 mu M is found. The developed technology has been patented. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：343 / 349

页数：7

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