A brief review on DNA vaccines in the era of COVID-19

被引：74

作者：

Shafaati, Maryam ^{[1
]}

Saidijam, Massoud ^{[2
,3
]}

Soleimani, Meysam ^{[4
]}

Hazrati, Fereshte ^{[4
]}

Mirzaei, Rasoul ^{[5
]}

Amirheidari, Bagher ^{[6
,7
]}

Tanzadehpanah, Hamid ^{[2
,3
]}

Karampoor, Sajad ^{[8
]}

Kazemi, Sima ^{[5
]}

Yavari, Bahram ^{[2
,3
]}

Mahaki, Hanie ^{[9
]}

Safaei, Mohsen ^{[10
]}

Rahbarizadeh, Fatemeh ^{[11
]}

Samadi, Pouria ^{[2
,3
]}

Ahmadyousefi, Yaghoub ^{[2
,3
]}

机构：

[1] Islamic Azad Univ, Fac Sci, Dept Microbiol, Jahrom Branch, Jahrom, Iran

[2] Hamadan Univ Med Sci, Sch Adv Med Sci & Technol, Dept Med Biotechnol, Hamadan, Hamadan, Iran

[3] Hamadan Univ Med Sci, Sch Med, Res Ctr Mol Med, Hamadan, Hamadan, Iran

[4] Hamadan Univ Med Sci, Sch Med, Dept Pharmaceut Biotechnol, Hamadan, Hamadan, Iran

[5] Hamadan Univ Med Sci, Sch Med, Dept Microbiol, Hamadan, Hamadan, Iran

[6] Kerman Univ Med Sci, Dept Pharmaceut Biotechnol, Fac Pharm, Kerman, Iran

[7] Kerman Univ Med Sci, Extremophile & Prod Microorganisms Res Ctr, Kerman, Iran

[8] Iran Univ Med Sci, Sch Med, Dept Virol, Tehran, Iran

[9] Mashhad Univ Med Sci, Vasc & Endovasc Surg Res Ctr, Mashhad, Razavi Khorasan, Iran

[10] Shahrekord Univ Med Sci, Sch Adv Technol, Dept Med Biotechnol, Shahrekord, Iran

[11] Tarbiat Modares Univ, Fac Med Sci, Dept Med Biotechnol, Tehran, Iran

来源：

FUTURE VIROLOGY | 2022年 / 17卷 / 01期

关键词：

COVID-19; DNA; DNA vaccines; nucleic acid vaccines; SARS-CoV-2; vaccines; WEST NILE VIRUS; NUCLEAR-LOCALIZATION SIGNAL; PLASMID DNA; GENE-THERAPY; TRANSGENE EXPRESSION; INTRAMUSCULAR INJECTION; NEUTRALIZING ANTIBODY; DENDRITIC CELLS; HEALTHY-ADULTS; DELIVERY;

D O I：

10.2217/fvl-2021-0170

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

This article provides a brief overview of DNA vaccines. First, the basic DNA vaccine design strategies are described, then specific issues related to the industrial production of DNA vaccines are discussed, including the production and purification of DNA products such as plasmid DNA, minicircle DNA, minimalistic, immunologically defined gene expression (MIDGE) and Doggybone (TM). The use of adjuvants to enhance the immunogenicity of DNA vaccines is then discussed. In addition, different delivery routes and several physical and chemical methods to increase the efficacy of DNA delivery into cells are explained. Recent preclinical and clinical trials of DNA vaccines for COVID-19 are then summarized. Lastly, the advantages and obstacles of DNA vaccines are discussed.

引用

页码：49 / 66

页数：18

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