Catalytic asymmetric synthesis of Leukotriene B4

被引：1

作者：

Yang, Pengfei ^{[1
]}

Zhong, Jiangchun ^{[1
]}

Ji, Kaijie ^{[1
]}

Yin, Jingwei ^{[1
]}

Li, Shuoning ^{[1
]}

Wei, Siyuan ^{[1
]}

Zhou, Yun ^{[1
]}

Wang, Lifeng ^{[1
]}

Wang, Min ^{[1
]}

Bian, Qinghua ^{[1
]}

机构：

[1] China Agr Univ, Dept Appl Chem, 2 West Yuanmingyuan Rd, Beijing 100193, Peoples R China

来源：

TETRAHEDRON-ASYMMETRY | 2017年 / 28卷 / 11期

关键词：

STEREOCONTROLLED TOTAL-SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; ARACHIDONIC-ACID; ADDITIONS; LTB4; B4;

D O I：

10.1016/j.tetasy.2017.09.013

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Leukotriene B-4 1 was prepared from two chiral synthons 8 and 14. The chiral secondary alcohols of 8 and 14 were constructed by BINOL/Ti(OiPr)(4) catalyzed enantioselective alkynylzinc addition to aldehydes. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：1596 / 1601

页数：6

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