One-Pot Synthesis of Quinoxalinones via Tandem Nitrosation/Cyclization of N-Aryl Cyanoacetamides

被引：21

作者：

Wang, Fang ^{[1
]}

Hu, Bo-Lun ^{[1
]}

Liu, Lizhi ^{[2
]}

Tu, Hai-Yong ^{[1
]}

Zhang, Xing-Guo ^{[1
]}

机构：

[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Peoples R China

[2] Guangzhou Ctr Dis Control & Prevent, Guangzhou 51440, Guangdong, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 82卷 / 20期

基金：

中国国家自然科学基金;

关键词：

CHIRAL QUINOXALINONES; HINSBERG REACTION; BOND FORMATION; C-N; QUINOXALIN-2(1H)-ONES; DERIVATIVES; CYCLIZATION; INHIBITORS; CASCADE; AGENTS;

D O I：

10.1021/acs.joc.7b01930

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new one-pot strategy for the synthesis of quinoxalin-2-ones from the tandem nitrosation/cyclization reaction of N-aryl cyanoacetamides with tert-butyl nitrite has been developed. The dehydrogenative N-incorporation is achieved through a sequence of nitrosation, tautomerization, and cyclization, affording quinoxalin-2-ones in moderate to good yields with good functional group tolerance.

引用

页码：11247 / 11252

页数：6

共 41 条

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