Immunization against Hepatitis E

被引：21

作者：

Innis, Bruce L. ^{[1
]}

Lynch, Julia A. ^{[2
]}

机构：

[1] PATH, Ctr Vaccine Innovat & Access, Washington, DC 20001 USA

[2] Int Vaccine Inst, SNU Res Pk, Seoul 08826, South Korea

来源：

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2018年 / 8卷 / 11期

关键词：

NON-B-HEPATITIS; TRANSMITTED NON-A; E VIRUS HEV; E VACCINE; CYNOMOLGUS MACAQUES; PROTOTYPE STRAIN; ETIOLOGIC AGENT; INSECT CELLS; NEPAL; ANTIBODY;

D O I：

10.1101/cshperspect.a032573

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Soon after the 1991 molecular cloning of hepatitis E virus (HEV), recombinant viral capsid antigens were expressed and tested in nonhuman primates for protection against liver disease and infection. Two genotype 1 subunit vaccine candidates entered clinical development: a 56 kDA vaccine expressed in insect cells and HEV 239 vaccine expressed in Escherichia coli. Both were highly protective against hepatitis E and acceptably safe. The HEV 239 vaccine was approved in China in 2011, but it is not yet prequalified by the World Health Organization, a necessary step for introduction into those low- and middle-income countries where the disease burden is highest. Nevertheless, the stage is set for the final act in the hepatitis E vaccine story-policymaking, advocacy, and pilot introduction of vaccine in at-risk populations, in which it is expected to be cost-effective.

引用

页数：17

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