Complement and viral pathogenesis

被引：194

作者：

Stoermer, Kristina A. ^{[1
,2
,3
]}

Morrison, Thomas E. ^{[1
,2
]}

机构：

[1] Univ Colorado, Sch Med, Dept Microbiol, Aurora, CO 80045 USA

[2] Univ Colorado, Dept Immunol, Sch Med, Aurora, CO 80045 USA

[3] Univ Colorado, Grad Program Immunol, Sch Med, Aurora, CO 80045 USA

来源：

VIROLOGY | 2011年 / 411卷 / 02期

关键词：

Complement; Virus; Pathogenesis; HERPES-SIMPLEX-VIRUS; HEPATITIS-C VIRUS; MANNOSE-BINDING LECTIN; RESPIRATORY SYNDROME CORONAVIRUS; ANTIBODY-DEPENDENT ENHANCEMENT; WEST-NILE-VIRUS; BLOOD DENDRITIC CELLS; HCV CORE PROTEIN; GLYCOPROTEIN-C; INFLUENZA-VIRUS;

D O I：

10.1016/j.virol.2010.12.045

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The complement system functions as an immune surveillance system that rapidly responds to infection. Activation of the complement system by specific recognition pathways triggers a protease cascade, generating cleavage products that function to eliminate pathogens, regulate inflammatory responses, and shape adaptive immune responses. However, when dysregulated, these powerful functions can become destructive and the complement system has been implicated as a pathogenic effector in numerous diseases, including infectious diseases. This review highlights recent discoveries that have identified critical roles for the complement system in the pathogenesis of viral infection. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：362 / 373

页数：12

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