Icetexane Diterpenoids from Perovskia atriplicifolia

被引：25

作者：

Jiang, Zhi-Yong ^{[1
]}

Yu, Yi-Jiang ^{[1
]}

Huang, Chao-Guan ^{[1
]}

Huang, Xiang-Zhong ^{[1
,2
]}

Hu, Qiu-Fen ^{[1
]}

Yang, Guang-Yu ^{[3
]}

Wang, Hong-Bin ^{[1
]}

Zhang, Xiang-Yu ^{[1
]}

Li, Gan-Peng ^{[1
]}

机构：

[1] Yunnan Minzu Univ, Sch Chem & Biotechnol, Kunming 650500, Yunnan, Peoples R China

[2] Yunnan Minzu Univ, Key Lab Yi Med Resources Pharmacodynam Res, Kunming 650500, Yunnan, Peoples R China

[3] Yunnan Acad Tobacco Sci, Key Lab Tobacco Chem Yunnan Prov, Kunming, Yunnan, Peoples R China

来源：

PLANTA MEDICA | 2015年 / 81卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Perovskia atriplicifolia; Lamiaceae; icetexane diterpenoids; anti-HBV activity; SALVIA; ROOTS;

D O I：

10.1055/s-0034-1396151

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new icetexane diterpenoids, namely, perovskatones B-D (1, 3, 4), 1-hydroxybrussonol (2), and 1-hydroxypisiferanol (5), were isolated from Perovskia atriplicifolia, together with a new natural product (6) and two known compounds, przewalskin E (7) and brussonol (8). The structures of the new compounds were elucidated by detailed analyses of their MS, IR, 1D, and 2DNMR data. Compounds 1-8 were assayed for their inhibitory hepatitis B virus activities in the HepG 2.2.15 cell line. The results suggested that compounds 1 and 2 possessed noticeable anti-hepatitis B virus activity in vitro, suppressing the replication of hepatitis B virus DNA with selectivity index values of 154.3 and 137.7, respectively.

引用

页码：241 / 246

页数：6

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