Acyldifluoromethylation Enabled by NHC-Photoredox Cocatalysis

被引：32

作者：

Zhang, Bei ^{[2
]}

Wang, Jian ^{[1
,2
]}

机构：

[1] Anhui Normal Univ, Coll Chem & Mat Sci, Wuhu 241002, Peoples R China

[2] Tsinghua Univ, Sch Pharmaceut Sci, Beijing 100084, Peoples R China

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 20期

基金：

中国国家自然科学基金;

关键词：

VISIBLE-LIGHT; CATALYSIS; DIFLUOROMETHYLATION; FLUORINE; ALKENES; HALIDES;

D O I：

10.1021/acs.orglett.2c01375

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

With the continued interest in the properties of the difluoromethyl (CF2H) group, small molecules with alkyl-CF2H motifs have gained increasing attention. However, concise and efficient synthetic protocols to achieve these structures are still urgently needed. Herein, we report a new acyldifluoromethylation of inert alkenes via a synergistic NHC-photoredox catalysis featuring broad substrate scope and good functional group tolerance.

引用

页码：3721 / 3725

页数：5

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